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Details on Person Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)

Class:Id	Reaction:392831
_displayName	Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
_doRelease	TRUE
_timestamp	2010-12-02 14:33:37
authored	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:392833] Jupe, S, 2009-03-09 10:40:38
edited	[InstanceEdit:870306] Jupe, S, 2010-06-07
inferredFrom	[Reaction:425898] Calcium and Diacylglycerol activate Ras guanyl-releasing protein 2 [Mus musculus]
input	[DefinedSet:392488] CalDAG-GEFs [cytosol] [Homo sapiens] [SimpleEntity:114519] DAG [plasma membrane] [SimpleEntity:74016] Ca2+ [cytosol]
modified	[InstanceEdit:400659] Jupe, S, 2009-03-24 17:22:03 [InstanceEdit:425863] Jupe, S, 2009-06-08 [InstanceEdit:425903] Jupe, S, 2009-06-08 [InstanceEdit:427702] Jupe, S, 2009-06-23 [InstanceEdit:428047] Jupe, S, 2009-06-30 [InstanceEdit:428048] Jupe, S, 2009-06-30 [InstanceEdit:430256] Jupe, S, 2009-08-06 [InstanceEdit:870283] Jupe, S, 2010-06-07 [InstanceEdit:870420] Jupe, S, 2010-06-08 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
output	[Complex:392841] CalDAG-GEFs:DAG:Ca2+ [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:114688] PLC-beta hydrolyses PIP2 to DAG and IP3 [Homo sapiens] [Reaction:8983510] PLC-beta:G-alpha(q/11) binds PIP2 [Homo sapiens] [Reaction:398193] PLC beta-mediated PIP2 hydrolysis [Homo sapiens] [Reaction:398040] Gbeta:gamma activation of PLC beta [Homo sapiens] [Reaction:114689] PLC gamma 2-mediated PIP2 hydrolysis [Homo sapiens] [BlackBoxEvent:429497] SLP-76 stimulates PLC gamma 2 [Homo sapiens] [Reaction:139854] IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol [Homo sapiens] [Reaction:139941] Binding of IP3 to IP3 receptor [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:870290] Kunapuli, SP, 2010-06-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104377] R-HSA-392831.2
summation	[Summation:392838] Calcium and DAG regulated guanine nucleotide exchange factor...
(hasEvent)	[Pathway:114508] Effects of PIP2 hydrolysis [Homo sapiens]
(precedingEvent)	[Reaction:354173] Activation of Rap1 by cytosolic GEFs [Homo sapiens] [Reaction:939265] Activation of Rap1 by membrane-associated GEFs [Homo sapiens]
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No pathways have been reviewed or authored by Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs) (392831)