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Details on Person Focal adhesion kinase 1 (PTK2, FAK, FAK1) acts downstream of...

Class:IdSummation:3928303
_displayNameFocal adhesion kinase 1 (PTK2, FAK, FAK1) acts downstream of...
_timestamp2013-10-03 08:56:42
created[InstanceEdit:3928288] Garapati, P V, 2013-07-22
literatureReference[LiteratureReference:3928042] Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity
[LiteratureReference:3928044] EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation
modified[InstanceEdit:4420372] Garapati, P V, 2013-09-03
[InstanceEdit:4640880] Garapati, P V, 2013-09-27
[InstanceEdit:4655451] Garapati, P V, 2013-10-03
textFocal adhesion kinase 1 (PTK2, FAK, FAK1) acts downstream of EPHB receptors in hippocampal neurons and the EPHB2-FAK signaling contributes to the dendritic spine morphogenesis and synapse maturation by suppressing the activity of actin severing cofilin through phosphorylation. Activation of EPHBs by ephrin-B (EFNB) stimulates the binding of FAK to EPHB. Knock out of FAK in mature neurons induces a shift of mushroom shaped mature dendritic spines to long filopodia like structures, suggesting that synapse formation or maturation is affected in FAK-/- neurons (Shi et al. 2009, Moeller et al. 2006).
(summation)[Reaction:3928588] EPHBs binds PTK2 [Homo sapiens]
[Reaction:3928630] EphBs binds Ptk2 [Mus musculus]
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