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Details on Person Focal adhesion kinase 1 (PTK2, FAK, FAK1) activation plays a...
| Class:Id | Summation:3928290 |
|---|---|
| _displayName | Focal adhesion kinase 1 (PTK2, FAK, FAK1) activation plays a... |
| _timestamp | 2013-10-03 08:56:40 |
| created | [InstanceEdit:3928288] Garapati, P V, 2013-07-22 |
| literatureReference | [LiteratureReference:3928042] Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity [LiteratureReference:372615] Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src |
| modified | [InstanceEdit:4420372] Garapati, P V, 2013-09-03 [InstanceEdit:4640880] Garapati, P V, 2013-09-27 [InstanceEdit:4655451] Garapati, P V, 2013-10-03 |
| text | Focal adhesion kinase 1 (PTK2, FAK, FAK1) activation plays a critical role in EPHB receptor signaling in dendritic spines. PTK2 has six tyrosine phosphorylation sites, with tyrosine 397 being the main auto-phosphorylation site present upstream of the kinase domain (Schaller et al. 1994). Activation of EPHB receptors induces long-lasting phosphorylation of PTK2 on tyrosine 397 (Shi et al. 2009). This phosphorylated tyrosine then creates a binding site for other signaling proteins that link PTK2 to downstream signaling pathways and actin cytoskeleton. |
| (summation) | [Reaction:3928599] Ptk2 autophosphorylates at Y397 [Mus musculus] [Reaction:3928610] PTK2 autophosphorylates at Y397 [Homo sapiens] |
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No pathways have been reviewed or authored by Focal adhesion kinase 1 (PTK2, FAK, FAK1) activation plays a... (3928290)
