Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person The effective activation of the EPH kinase domain requires o...

Class:IdSummation:3928275
_displayNameThe effective activation of the EPH kinase domain requires o...
_timestamp2013-10-03 08:57:27
created[InstanceEdit:3928288] Garapati, P V, 2013-07-22
literatureReference[LiteratureReference:3928081] Kinetic analysis of the binding of monomeric and dimeric ephrins to Eph receptors: correlation to function in a growth cone collapse assay
[LiteratureReference:3928014] Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses
[LiteratureReference:3928159] Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity
modified[InstanceEdit:4093236] Garapati, P V, 2013-08-14
[InstanceEdit:4640880] Garapati, P V, 2013-09-27
[InstanceEdit:4655451] Garapati, P V, 2013-10-03
textThe effective activation of the EPH kinase domain requires oligomerisation of EPH receptors and ephrins (EFNs) (Davis et al. 1994). Tetrameric EPH:EFN complexes aggregate into higher-ordered EPH:EFN clusters through several low-affinity EPH:EPH and EFN:EFN interactions, which may be responsible for EPH:EFN signaling (Stein et al. 1998, Pabbisetty et al. 2007).
(summation)[Polymerisation:3928591] EPH:EFN tetramers oligomerise [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by The effective activation of the EPH kinase domain requires o... (3928275)
Follow Reactome