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Details on Person T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1...
| Class:Id | Summation:3928274 |
|---|---|
| _displayName | T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1... |
| _timestamp | 2014-03-13 15:55:48 |
| created | [InstanceEdit:3928288] Garapati, P V, 2013-07-22 |
| literatureReference | [LiteratureReference:4093277] The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines |
| modified | [InstanceEdit:4505405] Garapati, P V, 2013-09-03 [InstanceEdit:4640880] Garapati, P V, 2013-09-27 [InstanceEdit:4655451] Garapati, P V, 2013-10-03 [InstanceEdit:5340292] Garapati, P V, 2014-03-13 |
| text | T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1) is a Rac1-specific GEF, highly expressed in the nervous system, which is necessary for proper spinal and synapse development. It is one of the critical mediators of NMDA receptor (NMDAR)-dependent spine development (Tolias et al. 2005). TIAM1 might also play a role in regulating EPHB-dependent spine morphogenesis. TIAM1 appears to be required for ephrinB (EFNB)-induced increase in spine density. TIAM1 is recruited to EPHB complexes containing NMDAR after EPHB receptor activation in neurons. The PH-CC-Ex (consisting of a pleckstrin homology (PH) domain followed by a coiled-coiled (CC) domain and an adjacent region (Ex) domain) of TIAM1 is required for binding to EPHB2 (Tolias et al. 2007). |
| (summation) | [Reaction:3928645] EPHB:NMDAR binds TIAM1 [Homo sapiens] |
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No pathways have been reviewed or authored by T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1... (3928274)
