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Details on Person Activated RHEA dimer binds to integrin beta subunit

Class:Id	Reaction:392326
_displayName	Activated RHEA dimer binds to integrin beta subunit
_doRelease	FALSE
_timestamp	2017-06-27 17:34:36
authored	[InstanceEdit:398231] Williams, MG, 2009-03-18 00:00:00
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:392341] Williams, MG, 2009-03-03 09:54:46
figure	[Figure:398243] /figures/DrosAIntegrin17.jpg
input	[Complex:398232] PIP2:Phospho PIP5K59B:RHEA dimer [plasma membrane] [Drosophila melanogaster] [Complex:398226] Integrin receptor:FAK56D:SRC [plasma membrane] [Drosophila melanogaster]
literatureReference	[LiteratureReference:377584] Structural basis of integrin activation by talin [LiteratureReference:392606] The talin-tail interaction places integrin activation on FERM ground [LiteratureReference:392544] Multiple factors contribute to integrin-talin interactions in vivo [LiteratureReference:392601] An interaction between integrin and the talin FERM domain mediates integrin activation but not linkage to the cytoskeleton
modified	[InstanceEdit:392662] Williams, MG, 2009-03-06 16:04:18 [InstanceEdit:398259] Williams, MG, 2009-03-18 14:53:21 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9010639] D'Eustachio, Peter, 2017-06-27
name	Activated RHEA dimer binds to integrin beta subunit
output	[Complex:398210] Integrin receptor:FAK56D:SRC:RHEA dimer:Phospho PIP5K59B:PIP2 [plasma membrane] [Drosophila melanogaster]
precedingEvent	[Reaction:392338] PIP2 activates RHEA which forms a homodimer [Drosophila melanogaster] [Reaction:392336] Activated phosphorylated PIP5K59B kinase phosphorylates PI4P at the plasma membrane [Drosophila melanogaster] [Reaction:392334] SRC:FAK kinases complex bind to inactive integrin beta subunit [Drosophila melanogaster]
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8912568] R-DME-392326.1
summation	[Summation:392565] At the cell surface, integrin alpha (MEW, IF, or SCB) and be...
(hasEvent)	[Pathway:392354] Activation of integrin receptor complex [Drosophila melanogaster]
(precedingEvent)	[Reaction:392347] Extracellular matrix ligands bind to integrin receptor complex [Drosophila melanogaster]
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No pathways have been reviewed or authored by Activated RHEA dimer binds to integrin beta subunit (392326)