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Details on Person G beta:gamma activated PI3Kgamma converts PIP2 to PIP3

Class:Id	Reaction:392300
_displayName	G beta:gamma activated PI3Kgamma converts PIP2 to PIP3
_doRelease	TRUE
_timestamp	2010-12-02 14:36:12
authored	[InstanceEdit:392294] Jupe, S, 2009-03-02 16:22:24
catalystActivity	[CatalystActivity:392298] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of G-protein beta-gamma:PI3K gamma [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:392299] Jupe, S, 2009-03-02 16:48:56
edited	[InstanceEdit:435389] Jupe, S, 2009-09-09
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:179856] PI(4,5)P2 [plasma membrane]
literatureReference	[LiteratureReference:425636] Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
modified	[InstanceEdit:392430] Jupe, S, 2009-03-03 10:52:03 [InstanceEdit:392449] Jupe, S, 2009-03-04 10:21:13 [InstanceEdit:400702] Jupe, S, 2009-03-24 18:03:07 [InstanceEdit:421581] Jupe, S, 2009-05-19 08:49:45 [InstanceEdit:421593] Jupe, S, 2009-05-19 09:02:56 [InstanceEdit:425632] Jupe, S, 2009-06-05 [InstanceEdit:430373] Jupe, S, 2009-08-07 [InstanceEdit:435202] Jupe, S, 2009-09-07 [InstanceEdit:435390] Jupe, S, 2009-09-09 [InstanceEdit:749449] Jupe, S, 2010-05-18 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	G beta:gamma activated PI3Kgamma converts PIP2 to PIP3
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:392295] Gbeta:gamma recruits PI3K gamma [Homo sapiens] [Reaction:392202] Dissociation of the P2Y purinoceptor 12:Gi complex [Homo sapiens] [Reaction:418576] Dissociation of the P2Y purinoceptor 1:Gq complex [Homo sapiens] [Reaction:397891] Thrombin-activated PARs:G12/13 (active) dissociate [Homo sapiens] [Reaction:397835] Thrombin-activated PARs:Gq (active) dissociate [Homo sapiens] [Reaction:392874] Dissociation of the Prostacyclin receptor:Gs complex [Homo sapiens] [Reaction:392021] Dissociation of the alpha-2 adrenergic receptor:Gz complex [Homo sapiens] [Reaction:751019] The Ligand:GPCR:G12/13 complex dissociates [Homo sapiens] [Reaction:749454] The Ligand:GPCR:Gi complex dissociates [Homo sapiens] [Reaction:749452] The Ligand:GPCR:Gq complex dissociates [Homo sapiens] [Reaction:744886] The Ligand:GPCR:Gs complex dissociates [Homo sapiens] [Reaction:751024] The Ligand:GPCR:Gz complex dissociates [Homo sapiens]
releaseDate	2009-09-30
reviewed	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104843] R-HSA-392300.2
summation	[Summation:425633] Biochemical and cellular studies have shown that the p101/p1...
(hasEvent)	[Pathway:392451] G beta:gamma signalling through PI3Kgamma [Homo sapiens]
(precedingEvent)	[Reaction:202692] PIP3 binds to RhoA and activates it [Homo sapiens] [Reaction:2316429] PIP3 recruits PDPK1 to the membrane [Homo sapiens] [Reaction:2317332] PIP3 recruits AKT to the membrane [Homo sapiens] [Reaction:9603279] PIP3 recruits PDK1 and AKT to the membrane [Homo sapiens]
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No pathways have been reviewed or authored by G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (392300)