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Details on Person G alpha (i) auto-inactivates by hydrolysing GTP to GDP

Class:Id	Reaction:392212
_displayName	G alpha (i) auto-inactivates by hydrolysing GTP to GDP
_doRelease	TRUE
_timestamp	2017-10-17 16:08:19
authored	[InstanceEdit:392218] Jupe, S, 2009-02-27 15:59:25
catalystActivity	[CatalystActivity:392204] GTPase activity of G alpha (i): GTP [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:392211] Jupe, S, 2009-02-27 15:56:33
edited	[InstanceEdit:435382] Jupe, S, 2009-09-09
inferredFrom	[Reaction:421896] G alpha (i)1 auto-inactivates by hydrolysing GTP to GDP [Rattus norvegicus]
input	[Complex:392161] G alpha (i): GTP [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:374843] Mechanism of GTP hydrolysis by G-protein alpha subunits
modified	[InstanceEdit:392217] Jupe, S, 2009-02-27 15:59:13 [InstanceEdit:392882] Jupe, S, 2009-03-09 15:49:43 [InstanceEdit:396916] Jupe, S, 2009-03-10 09:57:15 [InstanceEdit:400670] Jupe, S, 2009-03-24 17:44:19 [InstanceEdit:418577] Jupe, S, 2009-04-24 09:55:02 [InstanceEdit:421898] Jupe, S, 2009-05-22 12:08:35 [InstanceEdit:427686] Jupe, S, 2009-06-23 [InstanceEdit:430261] Jupe, S, 2009-08-06 [InstanceEdit:435175] Jupe, S, 2009-09-07 [InstanceEdit:435383] Jupe, S, 2009-09-09 [InstanceEdit:749449] Jupe, S, 2010-05-18 [InstanceEdit:8982644] Varusai, Thawfeek, 2017-03-21 [InstanceEdit:8982708] Varusai, Thawfeek, 2017-03-22 [InstanceEdit:9012089] Varusai, Thawfeek, 2017-07-11 [InstanceEdit:9026067] Jupe, Steve, 2017-10-17 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	G alpha (i) auto-inactivates by hydrolysing GTP to GDP
output	[Complex:392164] G-protein alpha (i):GDP [plasma membrane] [Homo sapiens] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:392202] Dissociation of the P2Y purinoceptor 12:Gi complex [Homo sapiens] [Reaction:392195] Gi activation by P2Y purinoceptor 12 [Homo sapiens] [Reaction:749454] The Ligand:GPCR:Gi complex dissociates [Homo sapiens] [Reaction:380073] Liganded Gi-activating GPCR acts as a GEF for Gi [Homo sapiens]
regulatedBy	[PositiveRegulation:921125] Positive regulation by 'RGS proteins active for G alpha (i) [plasma membrane]'
regulationReference	[RegulationReference:9642661] Positive regulation by 'RGS proteins active for G alpha (i) [plasma membrane]' Cellular regulation of RGS proteins: modulators and integrators of G protein signaling
releaseDate	2009-09-30
reviewed	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104115] R-HSA-392212.6
summation	[Summation:400669] When a ligand activates a G protein-coupled receptor, it ind...
(hasEvent)	[Pathway:418594] G alpha (i) signalling events [Homo sapiens]
(precedingEvent)	[Reaction:751001] Inactive G alpha (i) reassociates with G beta:gamma [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780430] Update Tracker - [Reaction:392212] G alpha (i) auto-inactivates by hydrolysing GTP to GDP - v63:[addOutput] [_UpdateTracker:9781360] Update Tracker - [Reaction:392212] G alpha (i) auto-inactivates by hydrolysing GTP to GDP - v61:[modifyText] [_UpdateTracker:9790208] Update Tracker - [Reaction:392212] G alpha (i) auto-inactivates by hydrolysing GTP to GDP - v34:[addRegulator] [_UpdateTracker:9790608] Update Tracker - [Reaction:392212] G alpha (i) auto-inactivates by hydrolysing GTP to GDP - v33:[modifyText]
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