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Details on Person Dissociation of the P2Y purinoceptor 12:Gi complex

Class:Id	Reaction:392202
_displayName	Dissociation of the P2Y purinoceptor 12:Gi complex
_doRelease	TRUE
_timestamp	2010-12-02 14:39:53
authored	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:392201] Jupe, S, 2009-02-27 15:44:57
edited	[InstanceEdit:445674] Jupe, S, 2009-11-03
input	[Complex:392194] ADP:P2RY12:G-protein Gi (active) [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:427945] Dissociation of heterotrimeric g proteins in cells
modified	[InstanceEdit:392214] Jupe, S, 2009-02-27 15:57:14 [InstanceEdit:418606] Jupe, S, 2009-04-24 10:40:08 [InstanceEdit:419434] Jupe, S, 2009-04-30 14:46:47 [InstanceEdit:428725] Jupe, S, 2009-07-08 [InstanceEdit:445664] Jupe, S, 2009-11-02 [InstanceEdit:446291] Jupe, S, 2009-11-12 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dissociation of the P2Y purinoceptor 12:Gi complex
output	[Complex:167434] G-protein beta-gamma complex [plasma membrane] [Homo sapiens] [SimpleEntity:114564] ADP [extracellular region] [EntityWithAccessionedSequence:391959] P2RY12 [plasma membrane] [Homo sapiens] [Complex:392161] G alpha (i): GTP [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:392195] Gi activation by P2Y purinoceptor 12 [Homo sapiens] [Reaction:392187] Activated P2Y purinoceptor 12 binds G-protein Gi [Homo sapiens]
releaseDate	2009-12-15
reviewed	[InstanceEdit:445650] Poole, AW, 2009-11-02 [InstanceEdit:445653] Jones, ML, 2009-11-02 [InstanceEdit:445649] Harper, MT, 2009-11-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105556] R-HSA-392202.2
summation	[Summation:392198] The classical view of G-protein signalling is that the G-pro...
(hasEvent)	[Pathway:392170] ADP signalling through P2Y purinoceptor 12 [Homo sapiens]
(precedingEvent)	[Reaction:392206] G alpha (i) inhibits adenylate cyclase [Homo sapiens] [Reaction:392212] G alpha (i) auto-inactivates by hydrolysing GTP to GDP [Homo sapiens] [Reaction:392295] Gbeta:gamma recruits PI3K gamma [Homo sapiens] [Reaction:398040] Gbeta:gamma activation of PLC beta [Homo sapiens] [Reaction:8964156] GNB1:GNG2 binds ARHGEF18 [Homo sapiens] [Reaction:8964241] G beta-gamma complex and PIP3 recruit BTK to membrane [Homo sapiens] [Reaction:8964302] G-protein beta-gamma complex binds to ITK [Homo sapiens] [Reaction:8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex [Homo sapiens] [Reaction:8978882] G-protein beta-gamma complex binds to voltage-gated calcium channel [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790605] Update Tracker - [Reaction:392202] Dissociation of the P2Y purinoceptor 12:Gi complex - v33:[modifyText]
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