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Details on Person The classical view of G-protein signalling is that the G-pro...

Class:IdSummation:392198
_displayNameThe classical view of G-protein signalling is that the G-pro...
_timestamp2010-05-26 08:46:59
created[InstanceEdit:392197] Jupe, S, 2009-02-27 15:43:19
literatureReference[LiteratureReference:751028] GTP binding to Gs does not promote subunit dissociation
modified[InstanceEdit:434709] Jupe, S, 2009-09-02
[InstanceEdit:751025] Jupe, S, 2010-05-19
[InstanceEdit:804958] Jupe, S, 2010-05-26
textThe classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (s) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).
(summation)[Reaction:392021] Dissociation of the alpha-2 adrenergic receptor:Gz complex [Homo sapiens]
[Reaction:392202] Dissociation of the P2Y purinoceptor 12:Gi complex [Homo sapiens]
[Reaction:392874] Dissociation of the Prostacyclin receptor:Gs complex [Homo sapiens]
[Reaction:397835] Thrombin-activated PARs:Gq (active) dissociate [Homo sapiens]
[Reaction:397891] Thrombin-activated PARs:G12/13 (active) dissociate [Homo sapiens]
[Reaction:418576] Dissociation of the P2Y purinoceptor 1:Gq complex [Homo sapiens]
[Reaction:421961] Dissociation of beta-2 adrenergic receptor:Gs complex [Oryctolagus cuniculus]
[Reaction:428752] Dissociation of the TP:Gq complex [Homo sapiens]
[Reaction:428918] Dissociation of the TP:G13 complex [Homo sapiens]
[Reaction:744886] The Ligand:GPCR:Gs complex dissociates [Homo sapiens]
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