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Details on Person Soluble guanylate cyclase converts GTP to cGMP

Class:Id	Reaction:392152
_displayName	Soluble guanylate cyclase converts GTP to cGMP
_doRelease	TRUE
_timestamp	2020-12-14 10:43:58
authored	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
catalystActivity	[CatalystActivity:392149] guanylate cyclase activity of Guanylate cyclase:NO [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:392151] Jupe, S, 2009-02-27 13:41:16
edited	[InstanceEdit:870305] Jupe, S, 2010-06-07
inferredFrom	[Reaction:427288] Soluble guanylate cyclase converts GTP to cGMP [Rattus norvegicus]
input	[SimpleEntity:29438] GTP [cytosol]
modified	[InstanceEdit:392156] Jupe, S, 2009-02-27 13:43:50 [InstanceEdit:392884] Jupe, S, 2009-03-09 15:52:31 [InstanceEdit:418439] Jupe, S, 2009-04-22 15:43:25 [InstanceEdit:419483] Jupe, S, 2009-05-01 15:33:06 [InstanceEdit:427292] Jupe, S, 2009-06-19 [InstanceEdit:435204] Jupe, S, 2009-09-07 [InstanceEdit:480990] Jupe, S, 2010-01-27 [InstanceEdit:870306] Jupe, S, 2010-06-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9620127] Jassal, Bijay, 2018-09-20 [InstanceEdit:9621180] Jassal, Bijay, 2018-09-26 [InstanceEdit:9628790] Jassal, Bijay, 2018-11-13 [InstanceEdit:9628791] Jassal, Bijay, 2018-11-13 [InstanceEdit:9709348] Stephan, Ralf, 2020-12-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Soluble guanylate cyclase converts GTP to cGMP
output	[SimpleEntity:30991] cGMP [cytosol] [SimpleEntity:111294] PPi [cytosol]
precedingEvent	[Reaction:392143] NO binds to Guanylate Cyclase [Homo sapiens] [Reaction:418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Homo sapiens] [BlackBoxEvent:9620097] NO translocates from mitochondrial matrix to cytosol [Homo sapiens]
regulatedBy	[PositiveRegulation:9621125] Positive regulation by 'NO:sGC:sGC stimulators [cytosol]' [PositiveRegulation:9621122] Positive regulation by 'NO:sGC:cinaciguat [cytosol]' [PositiveRegulation:478867] Positive regulation by 'NO [cytosol]' [PositiveRegulation:9709370] Positive regulation by 'Guanylate cyclase:CO [cytosol]'
regulationReference	[RegulationReference:9709389] Positive regulation by 'Guanylate cyclase:CO [cytosol]' Activation of soluble guanylate cyclase by carbon monoxide and inhibition by superoxide anion
releaseDate	2010-09-21
reviewed	[InstanceEdit:870290] Kunapuli, SP, 2010-06-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105826] R-HSA-392152.5
summation	[Summation:418437] Soluble guanylate cyclase (sGC) is a heterodimeric hemoprote...
(hasEvent)	[Pathway:392154] Nitric oxide stimulates guanylate cyclase [Homo sapiens] [Pathway:445355] Smooth Muscle Contraction [Homo sapiens]
(precedingEvent)	[Reaction:418451] cGMP stimulates Protein Kinase G [Homo sapiens] [Reaction:418456] cGMP is degraded by PDEs [Homo sapiens] [Reaction:9708129] PDE5A dimer hydrolyses cGMP to GMP [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776293] Update Tracker - [Reaction:392152] Soluble guanylate cyclase converts GTP to cGMP - v76:[addRegulator] [_UpdateTracker:9778958] Update Tracker - [Reaction:392152] Soluble guanylate cyclase converts GTP to cGMP - v67:[addRegulator]
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No pathways have been reviewed or authored by Soluble guanylate cyclase converts GTP to cGMP (392152)