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Details on Person Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate

Class:Id	Reaction:392129
_displayName	Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
_doRelease	TRUE
_timestamp	2020-02-24 17:12:50
authored	[InstanceEdit:421900] Jupe, S, 2009-05-22 13:10:56
catalystActivity	[CatalystActivity:392125] adenylate cyclase activity of G alpha (s):GTP:Adenylate cyclase [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:392130] Jupe, S, 2009-02-27 11:22:10
edited	[InstanceEdit:435382] Jupe, S, 2009-09-09
inferredFrom	[Reaction:421879] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate [Canis familiaris]
input	[SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:421881] Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles
modified	[InstanceEdit:392132] Jupe, S, 2009-02-27 11:38:00 [InstanceEdit:392215] Jupe, S, 2009-02-27 15:57:47 [InstanceEdit:400658] Jupe, S, 2009-03-24 17:18:09 [InstanceEdit:418732] Jupe, S, 2009-04-27 08:52:51 [InstanceEdit:420852] Jassal, Bijay, 2009-05-14 [InstanceEdit:421883] Jupe, S, 2009-05-22 08:45:12 [InstanceEdit:425217] Jupe, S, 2009-06-03 [InstanceEdit:430261] Jupe, S, 2009-08-06 [InstanceEdit:435178] Jupe, S, 2009-09-07 [InstanceEdit:435383] Jupe, S, 2009-09-09 [InstanceEdit:435383] Jupe, S, 2009-09-09 [InstanceEdit:500805] Jupe, S, 2010-02-05 [InstanceEdit:508592] Jupe, S, 2010-02-15 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8982644] Varusai, Thawfeek, 2017-03-21 [InstanceEdit:8982708] Varusai, Thawfeek, 2017-03-22 [InstanceEdit:9012089] Varusai, Thawfeek, 2017-07-11 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9623195] Rothfels, Karen, 2018-10-03 [InstanceEdit:9673290] Murillo, Julieth, 2020-01-07 [InstanceEdit:9673427] Murillo, Julieth, 2020-01-07 [InstanceEdit:9675996] Murillo, Julieth, 2020-02-06 [InstanceEdit:9676962] Murillo, Julieth, 2020-02-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
output	[SimpleEntity:30389] cAMP [cytosol] [SimpleEntity:111294] PPi [cytosol]
precedingEvent	[Reaction:392064] G alpha (z) inhibits adenylate cyclase [Homo sapiens] [Reaction:392021] Dissociation of the alpha-2 adrenergic receptor:Gz complex [Homo sapiens] [Reaction:380073] Liganded Gi-activating GPCR acts as a GEF for Gi [Homo sapiens] [Reaction:751024] The Ligand:GPCR:Gz complex dissociates [Homo sapiens] [Reaction:163617] G alpha (s) activates adenylate cyclase [Homo sapiens] [Reaction:392874] Dissociation of the Prostacyclin receptor:Gs complex [Homo sapiens] [Reaction:422320] Heterotrimeric G(s) complex dissociates [Homo sapiens] [Reaction:744886] The Ligand:GPCR:Gs complex dissociates [Homo sapiens] [Reaction:825631] Glucagon:GCGR mediates GTP-GDP exchange [Homo sapiens] [Reaction:9660819] ADORA2B:Ade-Rib:GsGTP dissociates [Homo sapiens] [Reaction:9861293] ADM:CALCRL:RAMP2:G-alpha(s):GTP:G-beta:G-gamma dissociates [Homo sapiens]
regulatedBy	[NegativeRegulation:392138] Negative regulation by 'G-protein alpha (z):GTP:Adenylate cyclase [plasma membrane]' [NegativeRegulation:500806] Negative regulation by 'G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane]'
releaseDate	2009-09-30
reviewed	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105517] R-HSA-392129.6
summation	[Summation:400657] The activation of adenylyl (adenylate) cyclase (AC) results ...
(hasEvent)	[Pathway:418555] G alpha (s) signalling events [Homo sapiens] [Pathway:418594] G alpha (i) signalling events [Homo sapiens] [Pathway:418597] G alpha (z) signalling events [Homo sapiens] [Pathway:9634597] GPER1 signaling [Homo sapiens] [Pathway:9660821] ADORA2B mediated anti-inflammatory cytokines production [Homo sapiens] [Pathway:9664309] C3AR1 mediated IL6 production [Homo sapiens] [Pathway:9665567] C3AR1 mediated synthesis of pro-inflammatory cytokines [Homo sapiens]
(precedingEvent)	[Reaction:418553] cAMP degradation by Phosphodiesterases [Homo sapiens] [Reaction:8951727] cAMP binds PKA tetramer [Homo sapiens] [Reaction:9629675] PDE3A hydrolyses cAMP to AMP [Homo sapiens] [Reaction:9705507] PDE3B hydrolyses cAMP to AMP [Homo sapiens] [Reaction:9708261] PDE4A hydrolyses cAMP to AMP [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778248] Update Tracker - [Reaction:392129] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate - v68:[modifyText] [_UpdateTracker:9778716] Update Tracker - [Reaction:392129] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate - v67:[removeRegulator] [_UpdateTracker:9790520] Update Tracker - [Reaction:392129] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate - v33:[addRegulator] [_UpdateTracker:9790972] Update Tracker - [Reaction:392129] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate - v32:[addRegulator]
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