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Details on Person Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
| Class:Id | LiteratureReference:392092 |
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| _displayName | Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation |
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| _timestamp | 2009-02-26 19:16:34 |
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| author | [Person:392104] Jaakkola, P
[Person:392107] Mole, DR
[Person:392079] Tian, YM
[Person:392096] Wilson, MI
[Person:392090] Gielbert, J
[Person:392088] Gaskell, SJ
[Person:392072] Kriegsheim, Av
[Person:392097] Hebestreit, HF
[Person:389586] Mukherji, Mridul
[Person:389606] Schofield, Christopher J
[Person:392089] Maxwell, PH
[Person:392087] Pugh, CW
[Person:392101] Ratcliffe, PJ |
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| created | [InstanceEdit:392093] Matthews, L, 2009-02-26 19:13:31 |
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| journal | Science |
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| modified | [InstanceEdit:392108] Matthews, L, 2009-02-26 19:14:16 |
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| pages | 468-72 |
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| pubMedIdentifier | 11292861 |
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| title | Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation |
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| volume | 292 |
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| year | 2001 |
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| (literatureReference) | [Pathway:390494] Cooperation of the Hsp70 and TRiC/CCT chaperone systems assembly of the VBC tumor suppressor complex [Homo sapiens]
[BlackBoxEvent:1234159] Proteasome proteolyzes ub-HIF-alpha [Homo sapiens]
[Reaction:1234169] Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha [Homo sapiens]
[Pathway:1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha [Homo sapiens]
[Reaction:1234177] Cytosolic PHD2,3 hydroxylates proline residues on HIF1A [Homo sapiens]
[Reaction:1234181] Nuclear PHD1,3 hydroxylates proline residues on HIF1A [Homo sapiens]
[Reaction:1234183] Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha [Homo sapiens]
[BlackBoxEvent:9755303] 26S proteasome degrades HIFalpha [Homo sapiens]
[Summation:391799] Inherited mutations in VHL gene result in von Hippel-Lindau ... |
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No pathways have been reviewed or authored by Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation (392092)
