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Details on Person Dissociation of the alpha-2 adrenergic receptor:Gz complex

Class:Id	Reaction:392021
_displayName	Dissociation of the alpha-2 adrenergic receptor:Gz complex
_timestamp	2016-07-15 23:50:09
authored	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:392022] Jupe, S, 2009-02-26 15:49:18
input	[Complex:392011] Catecholamine:Alpha-2 adrenoceptor:Heterotrimeric G-protein Gz (active) [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:427945] Dissociation of heterotrimeric g proteins in cells
modified	[InstanceEdit:392027] Jupe, S, 2009-02-26 15:52:30 [InstanceEdit:392196] Jupe, S, 2009-02-27 15:37:26 [InstanceEdit:392200] Jupe, S, 2009-02-27 15:44:49 [InstanceEdit:392213] Jupe, S, 2009-02-27 15:57:05 [InstanceEdit:418606] Jupe, S, 2009-04-24 10:40:08 [InstanceEdit:428746] Jupe, S, 2009-07-09 [InstanceEdit:430370] Jupe, S, 2009-08-07 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	Dissociation of the alpha-2 adrenergic receptor:Gz complex
output	[DefinedSet:390627] ADR, NAd [extracellular region] [DefinedSet:390664] ADRA2A,B,C [plasma membrane] [Homo sapiens] [Complex:392003] G-protein alpha (z):GTP [plasma membrane] [Homo sapiens] [Complex:167434] G-protein beta-gamma complex [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:392019] Gz activation by alpha 2 adrenoceptor [Homo sapiens] [Reaction:392018] Activated alpha-2 adrenoceptor binds G-protein Gz [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8912973] R-HSA-392021.1
summation	[Summation:392198] The classical view of G-protein signalling is that the G-pro...
(hasEvent)	[Pathway:392023] Adrenaline signalling through Alpha-2 adrenergic receptor [Homo sapiens]
(precedingEvent)	[Reaction:392064] G alpha (z) inhibits adenylate cyclase [Homo sapiens] [Reaction:392133] G alpha (z) auto-inactivates by hydrolysing GTP to GDP [Homo sapiens] [Reaction:392295] Gbeta:gamma recruits PI3K gamma [Homo sapiens] [Reaction:398040] Gbeta:gamma activation of PLC beta [Homo sapiens] [Reaction:8964241] G beta-gamma complex and PIP3 recruit BTK to membrane [Homo sapiens] [Reaction:8964302] G-protein beta-gamma complex binds to ITK [Homo sapiens] [Reaction:8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex [Homo sapiens] [Reaction:8978882] G-protein beta-gamma complex binds to voltage-gated calcium channel [Homo sapiens]
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