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Details on Person IP receptor can bind prostacyclin

Class:Id	Reaction:391942
_displayName	IP receptor can bind prostacyclin
_doRelease	TRUE
_timestamp	2016-03-04 16:47:04
authored	[InstanceEdit:416886] Jassal, Bijay, 2009-04-02
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:391938] Jassal, Bijay, 2009-02-25
edited	[InstanceEdit:416886] Jassal, Bijay, 2009-04-02
input	[EntityWithAccessionedSequence:391834] PTGIR [plasma membrane] [Homo sapiens] [SimpleEntity:391926] PGI2 [extracellular region]
literatureReference	[LiteratureReference:416922] Cloning and expression of a cDNA for the human prostanoid IP receptor [LiteratureReference:421911] Cloning and expression of a cDNA for the human prostacyclin receptor [LiteratureReference:416894] Differential activation of Gi and Gs proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL [LiteratureReference:421921] Functional and ligand binding studies suggest heterogeneity of platelet prostacyclin receptors [LiteratureReference:421915] The unique ligand-binding pocket for the human prostacyclin receptor. Site-directed mutagenesis and molecular modeling
modified	[InstanceEdit:391944] Jassal, Bijay, 2009-02-25 [InstanceEdit:416886] Jassal, Bijay, 2009-04-02 [InstanceEdit:416950] Jassal, Bijay, 2009-04-02 [InstanceEdit:420852] Jassal, Bijay, 2009-05-14 [InstanceEdit:420853] Jassal, Bijay, 2009-05-14 [InstanceEdit:422124] Jassal, Bijay, 2009-05-26 [InstanceEdit:422382] Jassal, Bijay, 2009-05-29 [InstanceEdit:532503] Jupe, S, 2010-03-01 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8863127] Jupe, Steve, 2016-03-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IP receptor can bind prostacyclin
output	[Complex:391929] PTGIR:PGI2 [plasma membrane] [Homo sapiens]
releaseDate	2009-06-24
reviewed	[InstanceEdit:422381] D'Eustachio, P, 2009-05-29 07:44:22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105956] R-HSA-391942.3
summation	[Summation:416887] Prostacyclin (PGI2) prevents formation of the platelet plug ...
(hasEvent)	[Pathway:391908] Prostanoid ligand receptors [Homo sapiens] [Pathway:392851] Prostacyclin signalling through prostacyclin receptor [Homo sapiens]
(precedingEvent)	[Reaction:392852] Activated prostacyclin receptor binds G-protein Gs [Homo sapiens] [Reaction:744887] Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs [Homo sapiens] [Reaction:9660828] ADORA2B:Ade-Rib binds heterometric G-protein Gs [Homo sapiens]
(replacementInstances)	[_Deleted:8875535] Deletion of instance: 392849
(updatedInstance)	[_UpdateTracker:9783055] Update Tracker - [Reaction:391942] IP receptor can bind prostacyclin - v57:[addLiteratureReference, modifyText]
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