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Details on Person Myosin light chain kinase (MLCK) is a serine/threonine-speci...
| Class:Id | Summation:391807 |
|---|---|
| _displayName | Myosin light chain kinase (MLCK) is a serine/threonine-speci... |
| _timestamp | 2009-06-03 17:25:19 |
| created | [InstanceEdit:391809] Garapati, P V, 2009-02-24 10:31:15 |
| literatureReference | [LiteratureReference:425324] Identification, phosphorylation, and dephosphorylation of a second site for myosin light chain kinase on the 20,000-dalton light chain of smooth muscle myosin [LiteratureReference:390714] Myosin light chain kinases [LiteratureReference:390716] Regulation of smooth muscle myosin light chain kinase by calmodulin |
| modified | [InstanceEdit:425325] Jupe, S, 2009-06-03 |
| text | Myosin light chain kinase (MLCK) is a serine/threonine-specific protein kinase that phosphorylates the myosin regulatory light chain (MRLC) of myosin 2. There are three MLCK genes in humans; the predominant smooth muscle and non-muscle form is encoded by the gene MYLK. MLCK is stimulated by calmodulin and hence by Ca2+ to phosphorylate the myosin regulatory light chain (MRLC) at serine-20. This enhances the ability of myosin to bind actin. In most, if not all, cell types, MRLC phosphorylation by MLCK is important for regulating actomyosin-based cytoskeletal functions such as focal adhesion and stress fiber formation, secretion, ion exchange, cytokinesis, neurite growth cone advancement, cell spreading, endothelial and epithelial barrier formation, and cell migration. In smooth muscle, this phosphorylation is important for the initiation of contraction. |
| (summation) | [Pathway:376174] Myosin Light Chain Kinase interactions [Homo sapiens] [Reaction:419235] Myosin regulatory light chain phosphorylation by myosin light chain kinase [Homo sapiens] [Reaction:421705] Myosin regulatory light chain phosphorylation (turkey) by myosin light chain kinase (turkey) [Meleagris gallopavo] |
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