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Details on Person Folding and assembly of VHL into the VHL-elongin BC (VBC) tu...
| Class:Id | Summation:391783 |
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| _displayName | Folding and assembly of VHL into the VHL-elongin BC (VBC) tu... |
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| _timestamp | 2015-11-24 19:01:50 |
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| created | [InstanceEdit:391778] Matthews, L, 2009-02-24 06:34:11 |
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| literatureReference | [LiteratureReference:391404] Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC
[LiteratureReference:391551] The Hsp70 and TRiC/CCT chaperone systems cooperate in vivo to assemble the von Hippel-Lindau tumor suppressor complex |
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| modified | [InstanceEdit:391802] Matthews, L, 2009-02-24 06:35:16
[InstanceEdit:392093] Matthews, L, 2009-02-26 19:13:31
[InstanceEdit:6813846] Orlic-Milacic, Marija, 2015-11-24 |
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| text | Folding and assembly of VHL into the VHL-elongin BC (VBC) tumor suppressor complex is directly mediated by the chaperonin TRiC/CCT (Feldman et al., 1999; Melville et al., 2003 ). The folding of VHL requires the cooperation of Hsp70 and TRiC. Hsp70 appears to promote substrate binding to TRiC (Melville et al., 2003 ). |
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| (summation) | [Reaction:390485] Association of VHL with Hsp70 and CCT/TriC [Homo sapiens] |
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