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Details on Person TSHR binds TSH/Thyrostimulin

Class:IdReaction:391375
_displayNameTSHR binds TSH/Thyrostimulin
_doReleaseTRUE
_timestamp2025-09-25 08:34:28
authored[InstanceEdit:391630] Jassal, Bijay, 2009-02-23
catalystActivity[CatalystActivity:9966646] thyroid-stimulating hormone receptor activity of TSHR [plasma membrane]
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created[InstanceEdit:391376] Jassal, Bijay, 2009-02-20
edited[InstanceEdit:391630] Jassal, Bijay, 2009-02-23
goBiologicalProcess[GO_BiologicalProcess:5083313] thyroid-stimulating hormone signaling pathway
input[EntityWithAccessionedSequence:391371] TSHR [plasma membrane] [Homo sapiens]
[DefinedSet:8942418] Thyrotropin, Thyrostimulin [extracellular region] [Homo sapiens]
internalReviewed[InstanceEdit:9967044] D'Eustachio, Peter, 2025-09-25
literatureReference[LiteratureReference:391585] Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor
[LiteratureReference:391602] The human thyrotropin receptor activates G-proteins Gs and Gq/11
[LiteratureReference:8942406] Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor
[LiteratureReference:9963123] TSH Receptor Cleavage Into Subunits and Shedding of the A-Subunit; A Molecular and Clinical Perspective
[LiteratureReference:9961312] Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion
[LiteratureReference:9963125] The Thyrotropin Receptor Mutation Database Update
[LiteratureReference:8942421] Thyrostimulin-TSHR signaling promotes the proliferation of NIH:OVCAR-3 ovarian cancer cells via trans-regulation of the EGFR pathway
[LiteratureReference:9963607] Current loss-of-function mutations in the thyrotropin receptor gene: when to investigate, clinical effects, and treatment
[LiteratureReference:9963613] Mechanisms of thyrotropin receptor-mediated phenotype variability deciphered by gene mutations and M453T-knockin model
[LiteratureReference:9963621] Genetic predisposition to papillary thyroid carcinoma: involvement of FOXE1, TSHR, and a novel lincRNA gene, PTCSC2
[LiteratureReference:9963631] Mutations of TSHR and TP53 Genes in an Aggressive Clear Cell Follicular Carcinoma of the Thyroid
[LiteratureReference:9963632] New Therapeutic Horizons for Graves' Hyperthyroidism
modified[InstanceEdit:391381] Jassal, Bijay, 2009-02-20
[InstanceEdit:391620] Jassal, Bijay, 2009-02-23
[InstanceEdit:392160] Jassal, Bijay, 2009-02-27
[InstanceEdit:392260] Jassal, Bijay, 2009-03-02
[InstanceEdit:420853] Jassal, Bijay, 2009-05-14
[InstanceEdit:422382] Jassal, Bijay, 2009-05-29
[InstanceEdit:532503] Jupe, S, 2010-03-01
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:8942409] Jupe, Steve, 2016-10-14
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9961392] Stephan, Ralf, 2025-07-25
[InstanceEdit:9963129] Stephan, Ralf, 2025-08-13
[InstanceEdit:9963629] Stephan, Ralf, 2025-08-15
[InstanceEdit:9963918] Stephan, Ralf, 2025-08-18
[InstanceEdit:9964258] Stephan, Ralf, 2025-08-21
[InstanceEdit:9964259] Stephan, Ralf, 2025-08-21
[InstanceEdit:9965884] Stephan, Ralf, 2025-09-06
[InstanceEdit:9966645] Stephan, Ralf, 2025-09-24
[InstanceEdit:9967043] Stephan, Ralf, 2025-09-25
nameTSHR binds TSH/Thyrostimulin
Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin
output[Complex:391374] TSHR:Thyrotropin [plasma membrane] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
releaseDate2009-04-01
reviewed[InstanceEdit:392262] D'Eustachio, P, 2009-03-02 09:24:35
reviewStatus[ReviewStatus:9821385] four stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:398395] R-HSA-391375.5
structureModified[InstanceEdit:9966645] Stephan, Ralf, 2025-09-24
summation[Summation:391613] Thyroid-stimulating hormone (TSH, thyrotropin) binds thyrotr...
(hasEvent)[Pathway:375281] Hormone ligand-binding receptors [Homo sapiens]
[Pathway:9961455] NEW: Regulation of thyroid hormone generation [Homo sapiens]
(precedingEvent)[Reaction:744887] Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs [Homo sapiens]
[Reaction:9660828] ADORA2B:Ade-Rib binds heterometric G-protein Gs [Homo sapiens]
(updatedInstance)[_UpdateTracker:9782236] Update Tracker - [Reaction:391375] Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin - v59:[addLiteratureReference, add_removeInput, modifyText]
[_UpdateTracker:9964635] Update Tracker - [Reaction:391375] TSHR binds TSH/Thyrostimulin - v94:[modifyText, removeLiteratureReference]
[_UpdateTracker:9971878] Update Tracker - [Reaction:391375] TSHR binds TSH/Thyrostimulin - v95:[removeCatalystActivity]
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