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Details on Person SIRP alpha binds CD47

Class:Id	Reaction:391158
_displayName	SIRP alpha binds CD47
_doRelease	TRUE
_timestamp	2013-03-04 15:46:32
authored	[InstanceEdit:391161] Garapati, P V, 2009-02-12 18:17:40
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:391154] Garapati, P V, 2009-02-12 18:16:59
edited	[InstanceEdit:391161] Garapati, P V, 2009-02-12 18:17:40
entityOnOtherCell	[EntityWithAccessionedSequence:197736] CD47 [plasma membrane] [Homo sapiens]
input	[EntityWithAccessionedSequence:3209922] SIRPA [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:197736] CD47 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:548966] Functional elements on SIRPalpha IgV domain mediate cell surface binding to CD47 [LiteratureReference:391061] Human signal-regulatory protein is expressed on normal, but not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counterreceptor CD47 [LiteratureReference:548955] The structure of the macrophage signal regulatory protein alpha (SIRPalpha) inhibitory receptor reveals a binding face reminiscent of that used by T cell receptors [LiteratureReference:548965] Structure of signal-regulatory protein alpha: a link to antigen receptor evolution [LiteratureReference:925200] Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47
modified	[InstanceEdit:548974] Garapati, P V, 2010-03-15 [InstanceEdit:763968] Garapati, P V, 2010-05-20 [InstanceEdit:847687] Garapati, P V, 2010-05-30 [InstanceEdit:925208] Garapati, P V, 2010-08-06 [InstanceEdit:3209923] Jassal, B, 2013-03-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SIRP alpha binds CD47
output	[Complex:391111] SIRPA:CD47 [plasma membrane] [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:763969] Barclay, AN, 2010-05-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104992] R-HSA-391158.2
summation	[Summation:391074] CD47 is an extracellular ligand for SIRP alpha. SIRP alpha d...
(hasEvent)	[Pathway:391160] Signal regulatory protein family interactions [Homo sapiens]
(precedingEvent)	[Reaction:391156] Phosphorylation of ITIM motif in SIRP alpha [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9787443] Update Tracker - [Reaction:391158] SIRP alpha binds CD47 - v45:[add_removeInput]
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No pathways have been reviewed or authored by SIRP alpha binds CD47 (391158)