Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
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Details on Person SIRP beta (SIRPB, CD172b) is expressed mainly on myeloid cel...
| Class:Id | Summation:391073 |
|---|---|
| _displayName | SIRP beta (SIRPB, CD172b) is expressed mainly on myeloid cel... |
| _timestamp | 2017-03-10 14:14:49 |
| created | [InstanceEdit:391072] Garapati, P V, 2009-02-12 17:51:32 |
| literatureReference | [LiteratureReference:210188] Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells [LiteratureReference:203245] The SIRP family of receptors and immune regulation |
| modified | [InstanceEdit:548912] Garapati, P V, 2010-03-15 [InstanceEdit:561256] Garapati, P V, 2010-03-31 [InstanceEdit:925208] Garapati, P V, 2010-08-06 [InstanceEdit:2426436] Garapati, P V, 2012-08-02 [InstanceEdit:8981541] Jupe, Steve, 2017-03-10 |
| text | SIRP beta (SIRPB, CD172b) is expressed mainly on myeloid cells and has a very short cytoplasmic region of only six amino acids, lacking the signaling motifs required for association with phosphatases that are found in SIRPA. Instead, SIRPB associates with a dimeric protein TYROBP (DAP12) to transmit activating signals via its ITAM motif. A positively charged amino acid in the transmembrane domain of TYROBP associates with a basic amino acid in the transmembrane region of SIRPB. |
| (summation) | [Reaction:210274] SIRP beta binds TYROBP [Homo sapiens] |
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No pathways have been reviewed or authored by SIRP beta (SIRPB, CD172b) is expressed mainly on myeloid cel... (391073)
