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Details on Person HTR1 and 5A receptors can bind serotonin

Class:Id	Reaction:390929
_displayName	HTR1 and 5A receptors can bind serotonin
_doRelease	TRUE
_timestamp	2020-07-01 11:13:56
authored	[InstanceEdit:390928] Jassal, Bijay, 2009-02-12
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:390928] Jassal, Bijay, 2009-02-12
edited	[InstanceEdit:390928] Jassal, Bijay, 2009-02-12
input	[DefinedSet:390959] HTR1B,D,E,F,HTR5A [plasma membrane] [Homo sapiens] [SimpleEntity:114523] 5HT [extracellular region]
literatureReference	[LiteratureReference:390945] Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HT1A receptor genes [LiteratureReference:390981] Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity [LiteratureReference:390946] Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta [LiteratureReference:390950] Human gene S31 encodes the pharmacologically defined serotonin 5-hydroxytryptamine1E receptor [LiteratureReference:391043] Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase [LiteratureReference:391006] Differential coupling of 5-HT(1) receptors to G proteins of the G(i) family [LiteratureReference:374957] The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells
modified	[InstanceEdit:390935] Jassal, Bijay, 2009-02-12 [InstanceEdit:392160] Jassal, Bijay, 2009-02-27 [InstanceEdit:392260] Jassal, Bijay, 2009-03-02 [InstanceEdit:420853] Jassal, Bijay, 2009-05-14 [InstanceEdit:422382] Jassal, Bijay, 2009-05-29 [InstanceEdit:432970] Jassal, Bijay, 2009-08-18 [InstanceEdit:532503] Jupe, S, 2010-03-01 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9648366] Jassal, Bijay, 2019-06-06 [InstanceEdit:9693345] Jassal, Bijay, 2020-07-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HTR1 and 5A receptors can bind serotonin
output	[Complex:390955] HTR1B,D,E,F,HTR5A:5HT [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:380901] Release of docked serotonin loaded synaptic vesicle [Homo sapiens] [Reaction:380905] Serotonin loaded synaptic vesicle docking and priming [Homo sapiens]
releaseDate	2009-04-01
reviewed	[InstanceEdit:392262] D'Eustachio, P, 2009-03-02 09:24:35
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:398407] R-HSA-390929.4
summation	[Summation:391038] 5-hydroxytryptamine receptors (HTRs), once bound to serotoni...
(hasEvent)	[Pathway:390666] Serotonin receptors [Homo sapiens]
(precedingEvent)	[Reaction:749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776707] Update Tracker - [Reaction:390929] HTR1 and 5A receptors can bind serotonin - v74:[modifyText] [_UpdateTracker:9791389] Update Tracker - [Reaction:390929] HTR1 and 5A receptors can bind serotonin - v30:[add_removeInput]
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