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| Class:Id | Summation:3907295 |
|---|---|
| _displayName | Laminin (LM) deposition onto the cell surface depends upon i... |
| _timestamp | 2013-07-19 16:00:54 |
| created | [InstanceEdit:3907301] Jupe, S, 2013-07-19 |
| literatureReference | [LiteratureReference:215355] Integrins as receptors for laminins [LiteratureReference:3900272] Structural requirement of carboxyl-terminal globular domains of laminin alpha 3 chain for promotion of rapid cell adhesion and migration by laminin-5 [LiteratureReference:3900289] Contributions of the LG modules and furin processing to laminin-2 functions [LiteratureReference:3900278] Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues [LiteratureReference:2396197] Beta1 integrin and alpha-dystroglycan binding sites are localized to different laminin-G-domain-like (LG) modules within the laminin alpha5 chain G domain [LiteratureReference:2396267] Ligand-binding specificities of laminin-binding integrins: a comprehensive survey of laminin-integrin interactions using recombinant alpha3beta1, alpha6beta1, alpha7beta1 and alpha6beta4 integrins [LiteratureReference:2426367] Mapping of network-forming, heparin-binding, and alpha 1 beta 1 integrin-recognition sites within the alpha-chain short arm of laminin-1 [LiteratureReference:2396131] The laminin alpha2-chain short arm mediates cell adhesion through both the alpha1beta1 and alpha2beta1 integrins [LiteratureReference:3900306] Identification of cell-binding sites on the Laminin alpha 5 N-terminal domain by site-directed mutagenesis [LiteratureReference:3900292] Domain IVa of laminin alpha5 chain is cell-adhesive and binds beta1 and alphaVbeta3 integrins through Arg-Gly-Asp [LiteratureReference:3900270] Keratinocyte migration requires alpha2beta1 integrin-mediated interaction with the laminin 5 gamma2 chain [LiteratureReference:1592404] Developmental and pathogenic mechanisms of basement membrane assembly |
| modified | [InstanceEdit:3907307] Jupe, S, 2013-07-19 |
| text | Laminin (LM) deposition onto the cell surface depends upon interactions with the LG domain located at the alpha chain C-terminus. The LM binding site for the major LM-binding integrins alpha6beta1, alpha6beta4, alpha3beta1 and alpha7beta1 (Belkin & Stepp 2000) is located in LG motifs 1–3 of LM alpha (LMA) chains (Hirosaki et al. 2000 - LMA3, unidentified integrin, Smirnov et al. 2002 - LMA2 with mouse alpha6beta1, Talts et al. 2000 - mouse LMA4 with integrin alpha6beta1, Yu & Talts 2003 - mouse LMA5 with integrin a3b1, Nishiuchi et al. 2006 - LMA1and LMA2 with alpha7Bbeta1). Recombinant integrins vary in their laminin specificites: alpha3beta1 and alpha6beta4 have a clear specificity for LM-332 and -511/512, integrin alpha6beta1 has a broad specificity, binding all LM isoforms with a preference for LM-111, -332 and -511/521. Alpha7beta1 variants do not bind LM-332. Alpha7 isoform X1beta1 binds all LM except LM-332, with a preference for LM-211/221 and LM-511/521, while alpha7 isoform X2beta1 binds preferentially to LM-111 and LM-211/221. LM-511/521 has the highest affinity for all LM-binding integrins except alpha7 isoform X2beta1, while LM-411 has low affinity only for alpha6beta1 and alpha7 isoform X1beta1 (Nishiuchi et al. 2006 - all human reagents except mouse LM-111). The N-terminal globular domains of LMA1 (Colognato-Pyke et al. 1995 - mouse LM, rat alpha1 and beta1 integrins) and alpha-2 chains (Colognato et al. 1997 - mouse LMA1, human LMA2, human integrins) can bind integrins alpha1beta1 and alpha2beta1. The N-terminal globular VI domains of LMA5 and LMA1 can bind integrin subunits alpha3, alpha2, alpha4, alpha6 (not LMA1) and beta1 (Nielsen & Yamada 2001 - using mouse LMA1 and LMA5 against Cercopithecus aethiops integrins). The IVa domain (L4a) domain of the LMA5 chain can bind integrin alphaVbeta3 (mouse LMA5, human integrin, Sasaki & Timpl 2001). The LM gamma-2 chain has been reported to bind alpha2beta1 integrin (Decline & Rousselle 2001). The N-terminal globular domains of some alpha chains can also bind sulfatides, which may also link the LM molecules to the cell surface. The relative importance of these interactions is unclear (Yurchenko & Patton 2009). Integrins and dystroglycan indirectly connect the LM network to the actin cytoskeleton. |
| (summation) | [Reaction:3907289] Integrin alpha6beta1, alpha7beta1, alpha1beta1, alpha2beta1, alphaVbeta1 bind laminin-111 [Homo sapiens] |
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