Query author contributions in Reactome
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Details on Person The inactive MLCK appears to have a catalytic domain that is...
| Class:Id | Summation:390715 |
|---|---|
| _displayName | The inactive MLCK appears to have a catalytic domain that is... |
| _timestamp | 2009-05-05 17:04:20 |
| created | [InstanceEdit:390718] Garapati, P V, 2009-02-10 10:32:06 |
| literatureReference | [LiteratureReference:390716] Regulation of smooth muscle myosin light chain kinase by calmodulin |
| modified | [InstanceEdit:419692] Jupe, S, 2009-05-05 17:05:24 |
| text | The inactive MLCK appears to have a catalytic domain that is repressed by a substrate inhibitory domain that overlaps with the CaM binding domain, a basic amphipathic helix. In the presence of Ca2+, CaM undergoes a conformational change that exposes two hydrophobic pockets, one in each globular lobe, which are important for binding to MLCK. Upon binding CaM, MLCK undergoes a conformational change that de-represses the catalytic site, allows substrate access and light chain phosphorylation. |
| (summation) | [Reaction:376133] MLCK binds Ca++:calmodulin [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by The inactive MLCK appears to have a catalytic domain that is... (390715)
