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Details on Person Like neurexins, Receptor-like protein tyrosine phosphatases ...

Class:IdSummation:390707
_displayNameLike neurexins, Receptor-like protein tyrosine phosphatases ...
_timestamp2017-01-06 10:07:52
created[InstanceEdit:390712] Garapati, P V, 2009-02-10 10:31:48
literatureReference[LiteratureReference:388632] LAR, liprin alpha and the regulation of active zone morphogenesis
[LiteratureReference:6797811] IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ
[LiteratureReference:6800388] Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule
[LiteratureReference:6800373] Mechanisms of splicing-dependent trans-synaptic adhesion by PTPδ-IL1RAPL1/IL-1RAcP for synaptic differentiation
[LiteratureReference:6798242] Postsynaptic TrkC and presynaptic PTPσ function as a bidirectional excitatory synaptic organizing complex
[LiteratureReference:6797909] Selective control of inhibitory synapse development by Slitrk3-PTPδ trans-synaptic interaction
[LiteratureReference:6800374] Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases
[LiteratureReference:388639] Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins
[LiteratureReference:6799307] LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses
modified[InstanceEdit:6800477] Garapati, Phani Vijay, 2015-09-29
[InstanceEdit:8954236] Jupe, Steve, 2017-01-06
textLike neurexins, Receptor-like protein tyrosine phosphatases (RPTPs) make trans-synaptic adhesion complexes with multiple postsynaptic binding partners to regulate synapse organization. The type IIa RPTPs include three members, Receptor-type tyrosine-protein phosphatase F (PTPRF) sometimes referred to as leukocyte common antigen-related (LAR), Receptor-type tyrosine-protein phosphatase sigma (PTPRS) and Receptor-type tyrosine-protein phosphatase delta (PTPRD). These proteins contain typical cell adhesion immunoglobulin-like (Ig) and fibronectin III (FNIII) domains, suggesting the involvement of RPTPs in cell-cell and cell-matrix interactions. To date, six different types of postsynaptic organizers for type-IIa RPTPs have been reported: interleukin-1 receptor accessory protein (IL1RAP, IL-1RAcP) (Yoshida et al. 2012), IL-1RAcP-like-1 (IL1RAPL1) (Yoshida et al. 2011), Neurotrophin receptor tyrosine kinase 3 (NTRK3, TrkC) (Takahashi et al. 2011), Leucine-rich repeat-containing protein 4B (LRRC4B, Netrin-G ligand-3, NGL-3) (Woo et al. 2009, Kwon et al. 2010), the Slit- and Trk-like (Slitrk) family proteins (Takahashi et al. 2012, Yim et al. 2013, Yamagata et al. 2015) and the liprins (Serra-Pagès et al. 1998, Dunah et al. 2005).
(summation)[Pathway:388844] Receptor-type tyrosine-protein phosphatases [Homo sapiens]
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