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Details on Person Dephosphorylation of AKT by PP2A

Class:Id	Reaction:390329
_displayName	Dephosphorylation of AKT by PP2A
_doRelease	TRUE
_timestamp	2017-12-01 14:27:22
authored	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
catalystActivity	[CatalystActivity:390328] phosphatidate phosphatase activity of PP2A [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:390332] Garapati, P V, 2009-01-26 10:07:27
edited	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
input	[CandidateSet:202074] p-T,p-S-AKT [cytosol] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:425541] Structure-Function analysis of the CTLA-4 interaction with PP2A
modified	[InstanceEdit:392680] Garapati, P V, 2009-03-06 16:21:30 [InstanceEdit:392693] Garapati, P V, 2009-03-06 16:41:35 [InstanceEdit:398059] Garapati, P V, 2009-03-16 14:08:25 [InstanceEdit:398108] Garapati, P V, 2009-03-16 18:06:35 [InstanceEdit:422361] D'Eustachio, P, 2009-05-28 17:55:23 [InstanceEdit:422523] Garapati, P V, 2009-06-01 19:10:10 [InstanceEdit:425542] Garapati, P V, 2009-06-05 [InstanceEdit:425944] Garapati, P V, 2009-06-09 [InstanceEdit:434622] Matthews, L, 2009-09-02 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9031660] Orlic-Milacic, Marija, 2017-12-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dephosphorylation of AKT by PP2A
output	[SimpleEntity:29372] Pi [cytosol] [CandidateSet:202088] AKT [cytosol] [Homo sapiens]
precedingEvent	[Reaction:388833] Phosphorylation of CTLA-4 [Homo sapiens] [Reaction:388809] CTLA-4 binds B7-1/B7-2 [Homo sapiens]
releaseDate	2009-09-30
reviewed	[InstanceEdit:422514] Bluestone, JA, Esensten, J, 2009-06-01 18:47:33
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105455] R-HSA-390329.3
summation	[Summation:390205] Upon engagement of CTLA4 by B7 molecules, PP2A dissociates f...
(hasEvent)	[Pathway:389513] Co-inhibition by CTLA4 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779708] Update Tracker - [Reaction:390329] Dephosphorylation of AKT by PP2A - v64:[add_removeInput, add_removeOutput] [_UpdateTracker:9928447] Update Tracker - [Reaction:390329] Dephosphorylation of AKT by PP2A - v91:[modifyText]
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