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Details on Person Conversion of glyoxylate to oxalate

Class:Id	Reaction:389862
_displayName	Conversion of glyoxylate to oxalate
_doRelease	TRUE
_timestamp	2024-12-04 22:39:49
authored	[InstanceEdit:389673] D'Eustachio, P, 2009-01-11 19:48:01
catalystActivity	[CatalystActivity:389855] glyoxylate oxidase activity of HAO1 tetramer [peroxisomal matrix]
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:389814] D'Eustachio, P, 2009-01-17 15:10:12
crossReference	[DatabaseIdentifier:9930614] RHEA:14838
edited	[InstanceEdit:392437] D'Eustachio, P, 2009-03-03 14:28:53
input	[SimpleEntity:389678] glyoxylate [peroxisomal matrix] [SimpleEntity:141343] H2O [peroxisomal matrix] [SimpleEntity:113535] O2 [peroxisomal matrix]
literatureReference	[LiteratureReference:389811] Identification and expression of a cDNA for human glycolate oxidase [LiteratureReference:389806] Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design [LiteratureReference:389858] Purification and characterization of recombinant human liver glycolate oxidase [LiteratureReference:389880] Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases
modified	[InstanceEdit:389866] D'Eustachio, P, 2009-01-17 15:10:52 [InstanceEdit:389878] D'Eustachio, P, 2009-01-19 22:06:33 [InstanceEdit:392219] D'Eustachio, P, 2009-02-27 16:52:08 [InstanceEdit:392438] D'Eustachio, P, 2009-03-03 14:30:54 [InstanceEdit:580605] D'Eustachio, P, 2010-04-11 [InstanceEdit:580606] D'Eustachio, P, 2010-04-11 [InstanceEdit:622406] Jassal, B, 2010-04-23 [InstanceEdit:6784433] D'Eustachio, Peter, 2015-06-19 [InstanceEdit:9012337] Jassal, Bijay, 2017-07-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9930615] D'Eustachio, Peter, 2024-12-04
name	Conversion of glyoxylate to oxalate glyoxylate + H2O + O2 => H(+) + H2O2 + oxalate
output	[SimpleEntity:389819] OX [peroxisomal matrix] [SimpleEntity:113575] H2O2 [peroxisomal matrix]
precedingEvent	[Reaction:389821] glycine + O2 => glyoxylate + H2O2 + NH4+ [Homo sapiens] [Reaction:389684] glyoxylate + alanine => glycine + pyruvate [peroxisome] [Homo sapiens] [Reaction:389842] HAO1 tetramer oxidizes glycolate to glyoxylate [Homo sapiens] [Reaction:389826] glyoxylate + NADPH + H+ => glycolate + NADP+ [Homo sapiens] [Reaction:8953430] PXMP2 trimer transports glycolate from cytosol to peroxisomal matrix [Homo sapiens] [BlackBoxEvent:6784434] An unknown carrier transports cytosolic glyoxylate to the peroxisome [Homo sapiens] [BlackBoxEvent:6784436] An unknown carrier transports mitochondrial glyoxylate to the cytosol [Homo sapiens]
releaseDate	2009-04-01
reviewed	[InstanceEdit:392439] Jassal, B, 2009-03-03 14:29:24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:398408] R-HSA-389862.5
summation	[Summation:389834] Peroxisomal hydroxyacid oxidase 1 catalyzes the reaction of ...
(hasEvent)	[Pathway:389661] Glyoxylate metabolism and glycine degradation [Homo sapiens]
(precedingEvent)	[Reaction:76031] 2 H2O2 => O2 + 2 H2O [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790792] Update Tracker - [Reaction:389862] Conversion of glyoxylate to oxalate - v33:[addInput, modifyText]
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No pathways have been reviewed or authored by Conversion of glyoxylate to oxalate (389862)