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Details on Person Phosphorylation of PD-1

Class:IdReaction:389762
_displayNamePhosphorylation of PD-1
_doReleaseTRUE
_timestamp2010-12-02 14:41:44
authored[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
catalystActivity[CatalystActivity:389761] protein tyrosine kinase activity of LCK, CSK [cytosol]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:389760] Garapati, P V, 2009-01-13 00:49:23
edited[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
input[Complex:388800] PDCD1:B7-DC,B7-H1 [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[DefinedSet:389743] LCK, CSK [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:389689] Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways
[LiteratureReference:389717] Cytotoxic T-lymphocyte antigen-4 and programmed death-1 function as negative regulators of lymphocyte activation
[LiteratureReference:389713] PD-1 and its ligands in tolerance and immunity
modified[InstanceEdit:389946] Garapati, P V, 2009-01-21 09:57:28
[InstanceEdit:392683] Garapati, P V, 2009-03-06 16:24:53
[InstanceEdit:392696] Garapati, P V, 2009-03-06 16:43:48
[InstanceEdit:398061] Garapati, P V, 2009-03-16 14:12:16
[InstanceEdit:398109] Garapati, P V, 2009-03-16 18:08:29
[InstanceEdit:422361] D'Eustachio, P, 2009-05-28 17:55:23
[InstanceEdit:422525] Garapati, P V, 2009-06-01 19:13:02
[InstanceEdit:425945] Garapati, P V, 2009-06-09
[InstanceEdit:434703] Matthews, L, 2009-09-02
[InstanceEdit:435026] Garapati, P V, 2009-09-04
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePhosphorylation of PD-1
output[Complex:389746] p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2009-09-30
reviewed[InstanceEdit:422514] Bluestone, JA, Esensten, J, 2009-06-01 18:47:33
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105882] R-HSA-389762.2
summation[Summation:389711] The cytoplasmic domain of PD-1 features two critical tyrosin...
(hasEvent)[Pathway:389948] Co-inhibition by PD-1 [Homo sapiens]
(precedingEvent)[Reaction:389759] Interaction of SHP-1 or SHP-2 with phospho PD-1 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9928444] Update Tracker - [Reaction:389762] Phosphorylation of PD-1 - v91:[modifyText]
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