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Details on Person PTPN6,PTPN11 [cytosol]

Class:IdDefinedSet:389744
_displayNamePTPN6,PTPN11 [cytosol]
_timestamp2015-03-20 08:56:47
compartment[Compartment:70101] cytosol
created[InstanceEdit:389745] Garapati, P V, 2009-01-13 00:45:22
hasMember
modified[InstanceEdit:5684162] Jupe, Steve, 2015-03-20
namePTPN6,PTPN11
SHP-2,SHP-1
SHP1,SHP2
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1108436] R-HSA-389744.1
(activeUnit)[CatalystActivity:389754] protein tyrosine phosphatase activity of PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane]
[CatalystActivity:914051] protein tyrosine phosphatase activity of High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane]
(hasComponent)[Complex:389749] PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] [Homo sapiens]
[Complex:389935] SHP-1/SHP-2:pBTLA:HVEM [plasma membrane] [Homo sapiens]
[Complex:391110] p-Y429,Y453,Y470,Y496-SIRPA:PTPN6,PTPN11 [plasma membrane] [Homo sapiens]
[Complex:914049] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] [Homo sapiens]
[Complex:914086] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] [Homo sapiens]
[Complex:5684187] G6B:PTPN6,PTPN11 [plasma membrane] [Homo sapiens]
(input)[Reaction:389759] Interaction of SHP-1 or SHP-2 with phospho PD-1 [Homo sapiens]
[Reaction:389941] SHP-1 and SHP-2 bind pBTLA [Homo sapiens]
[Reaction:391150] p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 [Homo sapiens]
[Reaction:909738] SHP1 and SHP2 bind the common beta chain [Homo sapiens]
[Reaction:5684169] G6B binds PTPN6,PTPN11 [Homo sapiens]
(regulator)[NegativeRegulation:912707] Negative regulation by 'PTPN6,PTPN11 [cytosol]'
(updatedInstance)[_UpdateTracker:9892472] Update Tracker - [DefinedSet:389744] PTPN6,PTPN11 [cytosol] - v53:[modifyName]
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No pathways have been reviewed or authored by PTPN6,PTPN11 [cytosol] (389744)
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