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Details on Person Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity

Class:IdLiteratureReference:389555
_displayNameStructures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity
_timestamp2009-01-07 23:42:17
author[Person:380057] Xu, X
[Person:389553] Zhao, J
[Person:389552] Xu, Z
[Person:389558] Peng, B
[Person:389554] Huang, Q
[Person:379997] Arnold, E
[Person:380041] Ding, Jianping
created[InstanceEdit:389551] D'Eustachio, P, 2009-01-07 23:42:02
journalJ Biol Chem
pages33946-57
pubMedIdentifier15173171
titleStructures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity
volume279
year2004
(literatureReference)[CatalystActivityReference:9643496] isocitrate dehydrogenase (NADP+) activity of IDH1 dimer [cytosol] Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
[Reaction:389540] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ [Homo sapiens]
[Reaction:389550] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ [Homo sapiens]
[Complex:389557] IDH1 dimer [peroxisomal matrix] [Homo sapiens]
[Complex:389559] IDH1 dimer [cytosol] [Homo sapiens]
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