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Details on Person isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+

Class:Id	Reaction:389550
_displayName	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
_doRelease	TRUE
_timestamp	2009-03-20 10:03:40
authored	[InstanceEdit:389547] D'Eustachio, P, 2009-01-07 23:39:54
catalystActivity	[CatalystActivity:389544] isocitrate dehydrogenase (NADP+) activity of IDH1 dimer [peroxisomal matrix]
catalystActivityReference	[CatalystActivityReference:9643511] isocitrate dehydrogenase (NADP+) activity of IDH1 dimer [peroxisomal matrix] Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:389551] D'Eustachio, P, 2009-01-07 23:42:02
edited	[InstanceEdit:389547] D'Eustachio, P, 2009-01-07 23:39:54
input	[SimpleEntity:389548] ISCIT [peroxisomal matrix] [SimpleEntity:389556] NADP+ [peroxisomal matrix]
literatureReference	[LiteratureReference:389555] Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity [LiteratureReference:389560] The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase
modified	[InstanceEdit:389566] D'Eustachio, P, 2009-01-10 16:30:06 [InstanceEdit:389800] D'Eustachio, P, 2009-01-16 16:46:20 [InstanceEdit:390345] D'Eustachio, P, 2009-01-26 14:17:36 [InstanceEdit:392189] D'Eustachio, P, 2009-02-27 15:24:50 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
output	[SimpleEntity:389537] 2OG [peroxisomal matrix] [SimpleEntity:389536] CO2 [peroxisomal matrix] [SimpleEntity:113602] NADPH [peroxisomal matrix] [SimpleEntity:193465] H+ [peroxisomal matrix]
precedingEvent	[Reaction:390347] Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane [Homo sapiens] [Reaction:389550] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ [Homo sapiens] [Reaction:5690911] ACO1:4Fe-4S isomerises CIT to ISCIT [Homo sapiens]
releaseDate	2009-04-01
reviewed	[InstanceEdit:392190] Jassal, Bijay, 2009-02-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:398361] R-HSA-389550.3
summation	[Summation:389541] Peroxisomal IDH1 (isocitrate dehydrogenase 1) homodimer cata...
(hasEvent)	[Pathway:389542] NADPH regeneration [Homo sapiens]
(precedingEvent)	[Reaction:389639] phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 [Homo sapiens] [Reaction:390347] Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane [Homo sapiens]
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No pathways have been reviewed or authored by isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (389550)