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Details on Person Cytosolic IDH1 (isocitrate dehydrogenase 1) homodimer cataly...
| Class:Id | Summation:389543 |
|---|---|
| _displayName | Cytosolic IDH1 (isocitrate dehydrogenase 1) homodimer cataly... |
| _timestamp | 2023-11-16 15:42:54 |
| created | [InstanceEdit:389551] D'Eustachio, P, 2009-01-07 23:42:02 |
| modified | [InstanceEdit:9853494] Stephan, Ralf, 2023-11-16 |
| text | Cytosolic IDH1 (isocitrate dehydrogenase 1) homodimer catalyzes the reaction of isocitrate and NADP+ to form 2-oxoglutarate, CO2, and NADPH + H+. The same enzyme can also localize to peroxisomes (Geisbrecht and Gould 1999; Xu et al. 2004). IDH1 doesn't seem to be part of a hypothetical cytosolic TCA cycle because its product 2-OG would have to be reimported into the mitochondrial matrix. However, the only known transporter of 2-OG, SLC25A12, mainly exports it in exchange with oxoadipate under normal physiological conditions (Fiermonte et al., 2001). |
| (summation) | [Reaction:389540] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ [Homo sapiens] |
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No pathways have been reviewed or authored by Cytosolic IDH1 (isocitrate dehydrogenase 1) homodimer cataly... (389543)
