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Details on Person isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+

Class:Id	Reaction:389540
_displayName	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
_doRelease	TRUE
_timestamp	2024-04-23 07:54:05
authored	[InstanceEdit:389547] D'Eustachio, P, 2009-01-07 23:39:54
catalystActivity	[CatalystActivity:389538] isocitrate dehydrogenase (NADP+) activity of IDH1 dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643496] isocitrate dehydrogenase (NADP+) activity of IDH1 dimer [cytosol] Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:389551] D'Eustachio, P, 2009-01-07 23:42:02
edited	[InstanceEdit:389547] D'Eustachio, P, 2009-01-07 23:39:54
input	[SimpleEntity:389545] ISCIT [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
literatureReference	[LiteratureReference:389560] The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase [LiteratureReference:389555] Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity [LiteratureReference:372484] Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution, and chromosomal location
modified	[InstanceEdit:389566] D'Eustachio, P, 2009-01-10 16:30:06 [InstanceEdit:389801] D'Eustachio, P, 2009-01-16 16:49:29 [InstanceEdit:392209] D'Eustachio, P, 2009-02-27 15:56:12 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9853494] Stephan, Ralf, 2023-11-16 [InstanceEdit:9908859] Stephan, Ralf, 2024-04-23
name	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
output	[SimpleEntity:29406] 2OG [cytosol] [SimpleEntity:113528] CO2 [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:5690911] ACO1:4Fe-4S isomerises CIT to ISCIT [Homo sapiens] [Reaction:5690873] ACO1 binds 4Fe-4S [Homo sapiens]
releaseDate	2009-04-01
reviewed	[InstanceEdit:392190] Jassal, Bijay, 2009-02-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:398436] R-HSA-389540.5
summation	[Summation:389543] Cytosolic IDH1 (isocitrate dehydrogenase 1) homodimer cataly...
(hasEvent)	[Pathway:389542] NADPH regeneration [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9863988] Update Tracker - [Reaction:389540] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ - v88:[addLiteratureReference, modifyText]
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