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Details on Person Translocation of Vav1 to CD28

Class:Id	Reaction:389352
_displayName	Translocation of Vav1 to CD28
_doRelease	TRUE
_timestamp	2017-12-01 11:42:58
authored	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:389353] Garapati, P V, 2009-01-06 13:42:50
edited	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
input	[SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane] [Complex:388786] CD28:Grb2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:195066] VAV1 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:389267] Tyrosine-phosphorylated Vav1 as a point of integration for T-cell receptor- and CD28-mediated activation of JNK, p38, and interleukin-2 transcription [LiteratureReference:389268] Vav-family proteins in T-cell signalling [LiteratureReference:389283] CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription
modified	[InstanceEdit:392683] Garapati, P V, 2009-03-06 16:24:53 [InstanceEdit:392696] Garapati, P V, 2009-03-06 16:43:48 [InstanceEdit:398062] Garapati, P V, 2009-03-16 14:13:12 [InstanceEdit:398109] Garapati, P V, 2009-03-16 18:08:29 [InstanceEdit:422361] D'Eustachio, P, 2009-05-28 17:55:23 [InstanceEdit:422525] Garapati, P V, 2009-06-01 19:13:02 [InstanceEdit:425946] Garapati, P V, 2009-06-09 [InstanceEdit:434703] Matthews, L, 2009-09-02 [InstanceEdit:507693] Garapati, P V, 2010-02-08 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9031648] Orlic-Milacic, Marija, 2017-12-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Translocation of Vav1 to CD28
output	[Complex:389334] VAV1:PIP3:CD28:GRB2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:388814] Grb2 binds CD28 [Homo sapiens] [Reaction:388831] Phosphorylation of CD28 [Homo sapiens] [Reaction:389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] [Reaction:388832] PI3K binds CD28 [Homo sapiens]
releaseDate	2009-09-30
reviewed	[InstanceEdit:422514] Bluestone, JA, Esensten, J, 2009-06-01 18:47:33
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104291] R-HSA-389352.3
summation	[Summation:389284] Vav1 protein is a cytoplasmic guanine nucleotide exchange fa...
(hasEvent)	[Pathway:389359] CD28 dependent Vav1 pathway [Homo sapiens]
(precedingEvent)	[Reaction:389354] Activation of Vav1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9928519] Update Tracker - [Reaction:389352] Translocation of Vav1 to CD28 - v91:[modifyText]
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