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Details on Person Itk binds CD28

Class:Id	Reaction:389349
_displayName	Itk binds CD28
_doRelease	FALSE
_timestamp	2016-07-15 23:49:57
authored	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:389353] Garapati, P V, 2009-01-06 13:42:50
edited	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
input	[Complex:388777] phospho CD28:B7-1/B7-2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:202319] ITK [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:389307] Itk is not essential for CD28 signaling in naive T cells [LiteratureReference:389310] Itk negatively regulates induction of T cell proliferation by CD28 costimulation [LiteratureReference:389341] The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28
modified	[InstanceEdit:392682] Garapati, P V, 2009-03-06 16:22:43 [InstanceEdit:392695] Garapati, P V, 2009-03-06 16:43:16 [InstanceEdit:398060] Garapati, P V, 2009-03-16 14:09:11 [InstanceEdit:398109] Garapati, P V, 2009-03-16 18:08:29 [InstanceEdit:422361] D'Eustachio, P, 2009-05-28 17:55:23 [InstanceEdit:422524] Garapati, P V, 2009-06-01 19:11:32 [InstanceEdit:425944] Garapati, P V, 2009-06-09 [InstanceEdit:434703] Matthews, L, 2009-09-02 [InstanceEdit:434984] Garapati, P V, 2009-09-04 [InstanceEdit:437257] Garapati, P V, 2009-09-14 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	Itk binds CD28
output	[Complex:389330] CD28:Itk [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:388831] Phosphorylation of CD28 [Homo sapiens] [Reaction:388811] CD28 homodimer binds B7-1 homodimer [Homo sapiens] [Reaction:388808] CD28 homodimer binds B7-2 monomer [Homo sapiens]
reviewed	[InstanceEdit:422514] Bluestone, JA, Esensten, J, 2009-06-01 18:47:33
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8908123] R-HSA-389349.1
summation	[Summation:389295] Following CD28 stimulation, Itk binds to CD28 and is tyrosin...
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No pathways have been reviewed or authored by Itk binds CD28 (389349)