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Details on Person Autophosphorylation of PDGF alpha receptors

Class:Id	Reaction:389083
_displayName	Autophosphorylation of PDGF alpha receptors
_doRelease	TRUE
_timestamp	2020-01-13 15:28:56
authored	[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
catalystActivity	[CatalystActivity:469651] protein tyrosine kinase activity of PDGF alpha receptor: PDGF dimers [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:389084] Garapati, P V, 2008-12-19 10:28:57
edited	[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
input	[Complex:389079] PDGF alpha receptor: PDGF dimers [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:380735] Signal transduction via platelet-derived growth factor receptors [LiteratureReference:9671886] Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies [LiteratureReference:9671319] A precision therapy against cancers driven by KIT/PDGFRA mutations [LiteratureReference:9674466] Response to a novel multitargeted tyrosine kinase inhibitor pazopanib in metastatic Merkel cell carcinoma [LiteratureReference:9673583] The role of small molecule platelet-derived growth factor receptor (PDGFR) inhibitors in the treatment of neoplastic disorders [LiteratureReference:9671447] Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases [LiteratureReference:9674290] The PDGF/PDGFR pathway as a drug target
modified	[InstanceEdit:392248] Garapati, P V, 2009-03-01 16:05:31 [InstanceEdit:469650] Garapati, P V, 2010-01-25 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9674474] Rothfels, Karen, 2020-01-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Autophosphorylation of PDGF alpha receptors
output	[Complex:389073] Phospho PDGF alpha receptor:PDGF dimers [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[BlackBoxEvent:186773] PDGF dimer binds two receptors simultaneously [Homo sapiens] [Reaction:186785] PDGF-AA clevage by Furin [Homo sapiens] [Reaction:8865276] PDGF-AB clevage by Furin [Homo sapiens] [Reaction:8865275] PDGF-BB clevage by Furin [Homo sapiens]
regulatedBy	[NegativeRegulation:9674157] Negative regulation by 'PDGFR:type I PDGFR-binding TKIs [plasma membrane]'
releaseDate	2009-04-01
reviewed	[InstanceEdit:382617] Heldin, CH, 2008-11-23 19:29:34
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:398422] R-HSA-389083.3
summation	[Summation:186790] Receptor dimerisation is key event in PDGF receptor activati...
(hasEvent)	[Pathway:186797] Signaling by PDGF [Homo sapiens]
(normalReaction)	[Reaction:9672175] Autophosphorylation of PDGFR mutant dimers [Homo sapiens]
(precedingEvent)	[Reaction:186765] PLC-gamma binds to the active receptor [Homo sapiens] [Reaction:186778] SHP2 binds to the active receptor [Homo sapiens] [Reaction:186780] PI3-kinase binds to the active receptor [Homo sapiens] [Reaction:186819] SH2 domain of Src binds to the active receptor [Homo sapiens] [Reaction:186826] GRB2:SOS1 complex binds to the active receptor [Homo sapiens] [Reaction:380782] STAT binds to the active receptor [Homo sapiens] [Reaction:382055] Grb7 binds to the active PDGF receptor [Homo sapiens] [Reaction:382056] Crk binds to the active PDGF receptor [Homo sapiens] [Reaction:382058] Nck binds to the active PDGF receptor [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777329] Update Tracker - [Reaction:389083] Autophosphorylation of PDGF alpha receptors - v72:[addLiteratureReference, addRegulator, modifyText] [_UpdateTracker:9791172] Update Tracker - [Reaction:389083] Autophosphorylation of PDGF alpha receptors - v32:[add_removeCatalystActivity]
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