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Query author contributions in Reactome

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Details on Person PI3K binds ICOS

Class:IdReaction:388830
_displayNamePI3K binds ICOS
_doReleaseTRUE
_timestamp2024-11-08 09:16:21
authored[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
[InstanceEdit:9927528] Garapati, Phani Vijay, 2024-11-07
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:388834] Garapati, P V, 2008-12-16 11:22:12
edited[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
input[EntityWithAccessionedSequence:389927] p-Y180-ICOS [plasma membrane] [Homo sapiens]
[CandidateSet:9927349] Class 1A PI3Ks [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:388700] A single amino acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible costimulator (ICOS)
modified[InstanceEdit:389947] Garapati, P V, 2009-01-21 09:57:39
[InstanceEdit:392682] Garapati, P V, 2009-03-06 16:22:43
[InstanceEdit:392695] Garapati, P V, 2009-03-06 16:43:16
[InstanceEdit:398061] Garapati, P V, 2009-03-16 14:12:16
[InstanceEdit:398109] Garapati, P V, 2009-03-16 18:08:29
[InstanceEdit:422361] D'Eustachio, P, 2009-05-28 17:55:23
[InstanceEdit:422525] Garapati, P V, 2009-06-01 19:13:02
[InstanceEdit:425945] Garapati, P V, 2009-06-09
[InstanceEdit:434703] Matthews, L, 2009-09-02
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9927359] Tiwari, Krishna, 2024-11-05
[InstanceEdit:9927591] Tiwari, Krishna, 2024-11-08
namePI3K binds ICOS
output[Complex:388785] ICOS:PI3K [plasma membrane] [Homo sapiens]
previousReviewStatus[ReviewStatus:9821384] two stars
regulatedBy[PositiveRegulation:9031652] Positive regulation by 'ICOS:ICOSL [plasma membrane]'
regulationReference[RegulationReference:9642610] Positive regulation by 'ICOS:ICOSL [plasma membrane]' ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse
releaseDate2009-09-30
reviewed[InstanceEdit:422514] Bluestone, JA, Esensten, J, 2009-06-01 18:47:33
[InstanceEdit:9927531] Matthews, Lisa, 2024-11-07
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104695] R-HSA-388830.5
structureModified[InstanceEdit:9927359] Tiwari, Krishna, 2024-11-05
summation[Summation:388730] ICOS ligation in T cells triggers the recruitment of PI3K, l...
(hasEvent)[Pathway:9927354] Co-stimulation by ICOS [Homo sapiens]
(precedingEvent)[Reaction:2316434] PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9780097] Update Tracker - [Reaction:388830] PI3K binds ICOS - v64:[addRegulator]
[_UpdateTracker:9928430] Update Tracker - [Reaction:388830] PI3K binds ICOS - v91:[add_removeInput, modifyText]
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No pathways have been reviewed or authored by PI3K binds ICOS (388830)
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