Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Programmed cell death protein 1 (PD-1, also known as PDCD1) ...
| Class:Id | Summation:388738 |
|---|---|
| _displayName | Programmed cell death protein 1 (PD-1, also known as PDCD1) ... |
| _timestamp | 2025-02-17 16:50:26 |
| created | [InstanceEdit:388731] Garapati, P V, 2008-12-16 10:42:53 |
| literatureReference | [LiteratureReference:388640] Differential binding properties of B7-H1 and B7-DC to programmed death-1 [LiteratureReference:9927287] Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability |
| modified | [InstanceEdit:422361] D'Eustachio, P, 2009-05-28 17:55:23 [InstanceEdit:422370] D'Eustachio, P, 2009-05-28 20:21:20 [InstanceEdit:434898] Garapati, P V, 2009-09-04 [InstanceEdit:9927288] Tiwari, Krishna, 2024-11-05 [InstanceEdit:9938518] Tiwari, Krishna, 2025-02-17 |
| text | Programmed cell death protein 1 (PD-1, also known as PDCD1) binds to its ligands, PD-L1 (B7-H1, also known as CD274) and PD-L2 (B7-DC, also known as PDCD1LG2 or CD273), to exert its inhibitory effects on T cell activation and immune response. PD-1 displays different affinities for these ligands, with the PD-1:PD-L2 interaction exhibiting a 2- to 6-fold higher affinity compared to the PD-1:PD-L1 interaction, along with distinct association and dissociation kinetics. This binding primarily occurs at the immune synapse, where PD-1 engagement with its ligands leads to the recruitment of phosphatases SHP-1 (PTPN6) and SHP-2 (PTPN11). These phosphatases dephosphorylate key signaling molecules in the T cell receptor (TCR) pathway, resulting in reduced T cell proliferation, cytokine production, and overall immune response. The interaction of PD-1 with its ligands is crucial for maintaining immune tolerance and preventing autoimmunity, as well as contributing to immune evasion in cancer (Youngnak et al. 2003, Pentcheva-Hoang et al. 2007). |
| (summation) | [Reaction:388828] PD-1 binds B7DC and B7H1 [Homo sapiens] [Reaction:9936162] PD-1 binds PD-L1,PD-L2 [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Programmed cell death protein 1 (PD-1, also known as PDCD1) ... (388738)
