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Details on Person WNTs bind the FZD receptor to initiate PCP pathway

Class:Id	Reaction:3858491
_displayName	WNTs bind the FZD receptor to initiate PCP pathway
_doRelease	TRUE
_timestamp	2024-03-07 02:48:25
authored	[InstanceEdit:3782517] Rothfels, K, 2013-06-28
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:3858492] Rothfels, K, 2013-07-09
edited	[InstanceEdit:4663813] Matthews, L, 2013-10-07
inferredFrom	[Reaction:4568832] Wnt11 binds Fzd7 to regulate convergent extension in Xenopus [Xenopus laevis]
input	[CandidateSet:3858485] PCP pathway FZDs [plasma membrane] [Homo sapiens] [CandidateSet:3858483] PCP pathway WNTs [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:4551415] Wnt regulation of planar cell polarity (PCP) [LiteratureReference:4551418] Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2 [LiteratureReference:4568826] Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis [LiteratureReference:4568829] The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells [LiteratureReference:4551435] Wnt5a functions in planar cell polarity regulation in mice [LiteratureReference:4568817] Frizzled6 controls hair patterning in mice [LiteratureReference:4568815] Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes
modified	[InstanceEdit:4568835] Rothfels, K, 2013-09-18 [InstanceEdit:5097320] Rothfels, K, 2013-11-11 [InstanceEdit:5144481] Rothfels, K, 2013-11-15 [InstanceEdit:8941679] Rothfels, Karen, 2016-10-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9864374] Orlic-Milacic, Marija, 2024-03-07
name	WNTs bind the FZD receptor to initiate PCP pathway
output	[Complex:3858486] WNT:FZD [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:3247843] secretion of WNT ligands [Homo sapiens] [BlackBoxEvent:3247844] WNT ligands traffic to the plasma membrane [Homo sapiens] [BlackBoxEvent:9830762] Expression of WNT11 in the nephric duct [Homo sapiens] [Reaction:9830754] GDNF from the metanephric mesenchyme binds RET:GFRA1 on the nephric duct [Homo sapiens] [BlackBoxEvent:9832331] Expression of WNT4 during nephron development [Homo sapiens] [BlackBoxEvent:9833362] Expression of WNT9B during nephron development [Homo sapiens]
releaseDate	2013-12-04
reviewed	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644946] R-HSA-3858491.4
summation	[Summation:4568809] Detailed biochemical analyses of all the WNT ligand-receptor...
(hasEvent)	[Pathway:4086400] PCP/CE pathway [Homo sapiens]
(precedingEvent)	[Reaction:3858482] DVL is recruited to the receptor [Homo sapiens]
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