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Details on Person WNT-dependent phosphorylation of DVL

Class:Id	Reaction:3858480
_displayName	WNT-dependent phosphorylation of DVL
_doRelease	TRUE
_timestamp	2014-11-20 02:43:01
authored	[InstanceEdit:3782517] Rothfels, K, 2013-06-28
catalystActivity	[CatalystActivity:5250906] protein serine/threonine kinase activity of unknown kinase [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:3858488] Rothfels, K, 2013-07-09
edited	[InstanceEdit:4663813] Matthews, L, 2013-10-07
inferredFrom	[Reaction:3858478] Rat Dvl is phosophorylated upon Wnt binding [Mus musculus]
input	[Complex:3858484] WNT:FZD:pDVL [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:3858424] Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin [LiteratureReference:3772339] Dishevelled: The hub of Wnt signaling [LiteratureReference:5099861] Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling
modified	[InstanceEdit:5097316] Rothfels, K, 2013-11-11 [InstanceEdit:5099855] Rothfels, K, 2013-11-13 [InstanceEdit:5144493] Rothfels, K, 2013-11-15 [InstanceEdit:5251669] Rothfels, K, 2014-02-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	WNT-dependent phosphorylation of DVL
output	[Complex:3858486] WNT:FZD [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [CandidateSet:3858467] pp-DVL [cytosol] [Homo sapiens]
precedingEvent	[Reaction:3858482] DVL is recruited to the receptor [Homo sapiens] [Reaction:3858491] WNTs bind the FZD receptor to initiate PCP pathway [Homo sapiens]
releaseDate	2013-12-04
reviewed	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644639] R-HSA-3858480.2
summation	[Summation:3858438] In response to WNT signaling, dishevelled (DVL) proteins are...
(hasEvent)	[Pathway:4086400] PCP/CE pathway [Homo sapiens]
(precedingEvent)	[Reaction:3858475] ppDVL recruits RAC [Homo sapiens] [Reaction:3858489] ppDVL binds DAAM1 [Homo sapiens] [NegativePrecedingEvent:9864365] Futile Cycle: WNT-dependent phosphorylation of DVL
(updatedInstance)	[_UpdateTracker:9777152] Update Tracker - [Reaction:3858480] WNT-dependent phosphorylation of DVL - v72:[modifyText] [_UpdateTracker:9786822] Update Tracker - [Reaction:3858480] WNT-dependent phosphorylation of DVL - v48:[add_removeCatalystActivity]
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