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Details on Person UniProt:P0C869 PLA2G4B

Class:Id	ReferenceGeneProduct:385773
_chainChangeLog	chain:1-781 added on Fri February 6 2015
_displayName	UniProt:P0C869 PLA2G4B
_timestamp	2025-02-21 19:30:43
chain	chain:1-781
checksum	4C5C6861E7BAB1B8
comment	FUNCTION Calcium-dependent phospholipase A1 and A2 and lysophospholipase that may play a role in membrane phospholipid remodeling.FUNCTION Calcium-dependent phospholipase A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-2 position of phosphatidylethanolamines, producing lysophospholipids that may be used in deacylation-reacylation cycles. Hydrolyzes lysophosphatidylcholines with low efficiency but is inefficient toward phosphatidylcholines.FUNCTION Calcium-dependent phospholipase A1 and A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-1 or sn-2 position of diacyl phospholipids (phospholipase A1 and A2 activity, respectively), producing lysophospholipids that may be used in deacylation-reacylation cycles. Can further hydrolyze lysophospholipids enabling complete deacylation. Has no activity toward alkylacyl phospholipids.CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)CATALYTIC ACTIVITY a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)CATALYTIC ACTIVITY 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoate + H(+)CATALYTIC ACTIVITY 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)CATALYTIC ACTIVITY 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)CATALYTIC ACTIVITY 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)CATALYTIC ACTIVITY 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)CATALYTIC ACTIVITY 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)CATALYTIC ACTIVITY 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)COFACTOR Stimulated by cytosolic Ca(2+).BIOPHYSICOCHEMICAL PROPERTIES The specific activity is 0.8 nmol/min/ug enzyme with 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine as substrate. The specific activity is 0.3 nmol/min/ug enzyme with 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine as substrate. The specific activity is 1.6 nmol/min/ug enzyme with 1-hexadecanoyl-sn-glycero-3-phosphocholine as substrate.BIOPHYSICOCHEMICAL PROPERTIES The specific activity is 2.1 nmol/min/ug enzyme with 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine as substrate. The specific activity is 0.6 nmol/min/ug enzyme with 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine as substrate. The specific activity is 140 nmol/min/ug enzyme with 1-hexadecanoyl-sn-glycero-3-phosphocholine as substrate.SUBCELLULAR LOCATION Translocates to membrane vesicles in a calcium-dependent fashion.SUBCELLULAR LOCATION Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas.DOMAIN The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).MISCELLANEOUS Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.MISCELLANEOUS Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.MISCELLANEOUS Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.CAUTION Most tissues also express read-through transcripts from this gene into the upstream gene (JMJD7), some of which may encode fusion proteins.SEQUENCE CAUTION Extended N-terminus.
created	[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
description	recommendedName: fullName evidence="10"Cytosolic phospholipase A2 beta shortName evidence="10"cPLA2-beta ecNumber evidence="4 5 7"3.1.1.4 alternativeName: fullName evidence="15"Lysophospholipase A1 group IVB ecNumber evidence="5 7"3.1.1.5 alternativeName: Phospholipase A2 group IVB
geneName	PLA2G4B
identifier	P0C869
isSequenceChanged	FALSE
keyword	Alternative splicing Calcium Cytoplasm Endosome Hydrolase Lipid degradation Lipid metabolism Membrane Metal-binding Mitochondrion Proteomics identification Reference proteome
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	PLA2G4B
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:5642216] ENSEMBL:ENSG00000243708 PLA2G4B [Homo sapiens]
secondaryIdentifier	PA24B_HUMAN B4DRT9 O95712 Q19KD5 Q19KD6 Q59GF9 Q8TB10 Q9UKV7
sequenceLength	781
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:385776] UniProt:P0C869-4 PLA2G4B [Homo sapiens] [ReferenceIsoform:402731] UniProt:P0C869-1 PLA2G4B [Homo sapiens] [ReferenceIsoform:8977527] UniProt:P0C869-6 PLA2G4B [Homo sapiens] [ReferenceIsoform:8977528] UniProt:P0C869-7 PLA2G4B [Homo sapiens] [ReferenceIsoform:8977529] UniProt:P0C869-8 PLA2G4B [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:535541] PLA2G4B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:1524130] PLA2G4B [mitochondrial inner membrane] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P0C869 PLA2G4B (385773)