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Details on Person RPS6KA1/2/3 phosphorylates CEBPB on S321

Class:Id	Reaction:3857328
_displayName	RPS6KA1/2/3 phosphorylates CEBPB on S321
_doRelease	TRUE
_timestamp	2017-02-22 09:53:50
authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
catalystActivity	[CatalystActivity:199892] protein serine/threonine kinase activity of Phospho-Ribosomal protein S6 kinase [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3857307] Orlic-Milacic, M, 2013-07-09
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
inferredFrom	[Reaction:3876071] RPS6KA1/2/3 phosphorylates Cebpb on S273 [Homo sapiens]
input	[EntityWithAccessionedSequence:3857343] p-T235-CEBPB [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:3857317] RSK-mediated phosphorylation in the C/EBP{beta} leucine zipper regulates DNA binding, dimerization, and growth arrest activity
modified	[InstanceEdit:3858388] Orlic-Milacic, M, 2013-07-09 [InstanceEdit:3876085] Orlic-Milacic, M, 2013-07-10 [InstanceEdit:3877064] Orlic-Milacic, M, 2013-07-10 [InstanceEdit:4415004] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:4416363] Orlic-Milacic, M, 2013-08-26 [InstanceEdit:4420304] Orlic-Milacic, M, 2013-09-03 [InstanceEdit:4420306] Orlic-Milacic, M, 2013-09-03 [InstanceEdit:4542310] Orlic-Milacic, M, 2013-09-04 [InstanceEdit:8979176] Orlic-Milacic, Marija, 2017-02-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RPS6KA1/2/3 phosphorylates CEBPB on S321
output	[SimpleEntity:113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:3857339] p-T235, S321-CEBPB [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:3857329] MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB [Homo sapiens] [BlackBoxEvent:5674387] Phosphorylated MAPKs translocate into the nucleus [Homo sapiens] [BlackBoxEvent:3858387] Activated STAT3 positively regulates CEBPB transcription [Homo sapiens] [Reaction:198746] ERK1/2/5 activate RSK1/2/3 [Homo sapiens] [Reaction:198714] ERK5 translocates to the nucleus [Homo sapiens] [BlackBoxEvent:5674387] Phosphorylated MAPKs translocate into the nucleus [Homo sapiens] [BlackBoxEvent:9610166] p-T,Y MAPK dimers translocate to nucleus [Homo sapiens]
releaseDate	2013-09-18
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:4545069] R-HSA-3857328.3
summation	[Summation:3858383] Phosphorylation of CEBPB (C/EBP-beta) serine residue S321 by...
(hasEvent)	[Pathway:2559582] Senescence-Associated Secretory Phenotype (SASP) [Homo sapiens]
(precedingEvent)	[Reaction:3857336] CEBPB homodimerization [Homo sapiens]
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