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Details on Person UniProt:B2RTY4-4 MYO9A
| Class:Id | ReferenceIsoform:385651 |
|---|---|
| _chainChangeLog | chain:1-2548 added on Sat February 7 2015 |
| _displayName | UniProt:B2RTY4-4 MYO9A |
| _timestamp | 2026-02-20 22:46:10 |
| chain | chain:1-2548 |
| checksum | 867835BD2B841C84 |
| comment | FUNCTION Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating its GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity).SUBCELLULAR LOCATION Localized in the cytoplasm of cell bodies, dendrites and axons with occasional hints of an enrichment near the plasma membrane. Localized at the neuromuscular junction (By similarity).ALTERNATIVE PRODUCTS Found to be expressed in testis and placenta and at lower levels in all the examined tissues with the exception of liver (PubMed:10409426). Isoform 5: Found in leukocytes but not in brain, retina or testis (PubMed:10409426).PTM Phosphorylated by ALPK1 following monosodium urate monohydrate (MSU)-induced inflammation.DISEASE The disease may be caused by variants affecting the gene represented in this entry.MISCELLANEOUS Lacks the ATP-binding domain which suggests that it cannot interact with actin.SIMILARITY Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.CAUTION Represents an unconventional myosin. This protein should not be confused with the conventional myosin-9 (MYH9).SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 |
| description | recommendedName: Unconventional myosin-IXa alternativeName: Unconventional myosin-9a |
| geneName | MYO9A MYR7 |
| identifier | B2RTY4 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Actin-binding Alternative splicing ATP-binding Cell projection Coiled coil Congenital myasthenic syndrome Cytoplasm Disease variant GTPase activation Membrane Metal-binding Motor protein Myosin Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Repeat Synapse Transmembrane Transmembrane helix Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | MYO9A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8954628] ENSEMBL:ENSG00000066933 MYO9A [Homo sapiens] |
| secondaryIdentifier | MYO9A_HUMAN B0I1T5 C9IYB3 C9JA86 Q14787 Q3YLD7 Q3YLD8 Q6P986 Q9H8T5 Q9NTG2 Q9NUY2 Q9UEP3 Q9UNJ2 |
| sequenceLength | 2548 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | B2RTY4-4 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:B2RTY4-4 MYO9A (385651)
