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Details on Person UniProt:Q6MZP7 LIN54
| Class:Id | ReferenceGeneProduct:385452 |
|---|---|
| _chainChangeLog | chain:1-749 added on Sat February 7 2015 |
| _displayName | UniProt:Q6MZP7 LIN54 |
| _timestamp | 2024-11-03 19:51:59 |
| chain | chain:1-749 |
| checksum | A3E4513CB0118B78 |
| comment | FUNCTION Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context (PubMed:17531812, PubMed:17671431). In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes (PubMed:17531812, PubMed:17671431). In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation (PubMed:17531812, PubMed:17671431). In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner (PubMed:19725879). Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA (PubMed:27465258).SUBUNIT Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.INTERACTION The CRC domain mediates DNA-binding (PubMed:19725879, PubMed:27465258). It contains two CXC subdomains (joined by a flexible linker) which are both required for efficient association with target DNA (PubMed:27465258). Each CXC subdomain coordinates three Zn(2+) ions (PubMed:27465258).SIMILARITY Belongs to the lin-54 family.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 |
| description | recommendedName: Protein lin-54 homolog alternativeName: CXC domain-containing protein 1 |
| geneName | LIN54 CXCDC1 KIAA2037 |
| identifier | Q6MZP7 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Activator Alternative splicing Cell cycle DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation Ubl conjugation Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | LIN54 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997247] ENSEMBL:ENSG00000189308 LIN54 [Homo sapiens] |
| secondaryIdentifier | LIN54_HUMAN Q32M68 Q32M69 Q6N071 Q76B60 |
| sequenceLength | 749 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:385453] UniProt:Q6MZP7-2 LIN54 [Homo sapiens] [ReferenceIsoform:385454] UniProt:Q6MZP7-3 LIN54 [Homo sapiens] [ReferenceIsoform:385455] UniProt:Q6MZP7-4 LIN54 [Homo sapiens] [ReferenceIsoform:385456] UniProt:Q6MZP7-5 LIN54 [Homo sapiens] [ReferenceIsoform:408306] UniProt:Q6MZP7-1 LIN54 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:389103] LIN54 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q6MZP7 LIN54 (385452)
