Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:A6NNW6 ENO4
| Class:Id | ReferenceGeneProduct:384959 |
|---|---|
| _chainChangeLog | chain:1-628 added on Fri February 6 2015;chain:1-628 for 384959 removed on Fri February 15 2019;chain:1-625 for 384959 added on Fri February 15 2019 |
| _displayName | UniProt:A6NNW6 ENO4 |
| _timestamp | 2026-02-20 22:32:00 |
| chain | chain:1-625 |
| checksum | 3FE6180EE2D83CE5 |
| comment | FUNCTION Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis (By similarity). May be required for sperm motility and function.CATALYTIC ACTIVITY (2R)-2-phosphoglycerate = phosphoenolpyruvate + H2OPATHWAY Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.SUBUNIT Interacts with ENO1 and AKAP4.ALTERNATIVE PRODUCTS Synthesized as an approximately 70-kDa precursor, which then undergoes proteolytic cleavage to an approximately 60-kDa enzyme; HOATZ associates directly or indirectly with ENO4 to mediate this process before its transport to mature flagella.SIMILARITY Belongs to the enolase family.CAUTION Although it belongs to the enolase family, Leu-362 is present instead of the conserved Glu which is expected to be an active site residue. |
| created | [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 |
| description | recommendedName: fullName evidence="2"Enolase 4 ecNumber evidence="2"4.2.1.11 alternativeName: 2-phospho-D-glycerate hydro-lyase |
| geneName | ENO4 C10orf134 |
| identifier | A6NNW6 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Glycolysis Lyase Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ENO4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996544] ENSEMBL:ENSG00000188316 ENO4 [Homo sapiens] |
| secondaryIdentifier | ENO4_HUMAN A0A087WZY6 A6NI74 B8ZZN9 J3KNX1 |
| sequenceLength | 625 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8967831] UniProt:A6NNW6-2 ENO4 [Homo sapiens] [ReferenceIsoform:9627812] UniProt:A6NNW6-3 ENO4 [Homo sapiens] [ReferenceIsoform:9627813] UniProt:A6NNW6-4 ENO4 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9820656] ENO4 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9966826] ENO4 [cilium] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:A6NNW6 ENO4 (384959)
