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Details on Person Glucagon-like Peptide 1 is secreted from intestinal L cells

Class:Id	BlackBoxEvent:383313
_displayName	Glucagon-like Peptide 1 is secreted from intestinal L cells
_doRelease	TRUE
_timestamp	2014-02-04 22:50:55
authored	[InstanceEdit:421433] May, B, 2009-05-18 21:31:59
compartment	[Compartment:984] extracellular region [Compartment:1462052] secretory granule lumen
edited	[InstanceEdit:435259] May, B, 2009-09-09
input	[DefinedSet:879886] mature GLP-1 [secretory granule lumen] [Homo sapiens]
literatureReference	[LiteratureReference:508114] Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP [LiteratureReference:508128] A human cellular model for studying the regulation of glucagon-like peptide-1 secretion [LiteratureReference:383303] GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion [LiteratureReference:382396] Muscarinic receptors control glucagon-like peptide 1 secretion by human endocrine L cells [LiteratureReference:382418] Role of leptin in the regulation of glucagon-like peptide-1 secretion [LiteratureReference:382304] Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2 [LiteratureReference:382392] Meat hydrolysate and essential amino acid-induced glucagon-like peptide-1 secretion, in the human NCI-H716 enteroendocrine cell line, is regulated by extracellular signal-regulated kinase1/2 and p38 mitogen-activated protein kinases [LiteratureReference:382313] Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120 [LiteratureReference:382398] Nutritional regulation of glucagon-like peptide-1 secretion [LiteratureReference:400463] Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion
modified	[InstanceEdit:383340] May, B, 2008-11-25 19:05:58 [InstanceEdit:400462] May, B, 2009-03-24 03:26:48 [InstanceEdit:421427] May, B, 2009-05-18 21:31:13 [InstanceEdit:422152] D'Eustachio, P, 2009-05-26 22:15:13 [InstanceEdit:422548] D'Eustachio, P, 2009-06-02 00:49:41 [InstanceEdit:434239] May, B, 2009-08-27 [InstanceEdit:435259] May, B, 2009-09-09 [InstanceEdit:435295] May, B, 2009-09-09 [InstanceEdit:508100] May, B, 2010-02-10 [InstanceEdit:508224] May, B, 2010-02-11 [InstanceEdit:771698] May, B, 2010-05-21 [InstanceEdit:847708] May, B, 2010-05-30 [InstanceEdit:879885] May, B, 2010-06-24 [InstanceEdit:927719] May, B, 2010-08-06 [InstanceEdit:2684523] D'Eustachio, P, 2012-11-30 [InstanceEdit:2976046] May, B, 2013-01-09 [InstanceEdit:5251722] May, B, 2014-02-04 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Glucagon-like Peptide 1 is secreted from intestinal L cells
output	[DefinedSet:381662] mature GLP1 [extracellular region] [Homo sapiens]
precedingEvent	[BlackBoxEvent:381798] PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 [Homo sapiens] [BlackBoxEvent:421416] Proglucagon translocates from the ER Lumen to secretory granules [Homo sapiens]
regulatedBy	[PositiveRegulation:400469] Positive regulation by 'GRP(24-50) [extracellular region]' [PositiveRegulation:400475] Positive regulation by 'LEP [extracellular region]' [PositiveRegulation:400505] Positive regulation by 'GPR119:monoacylglycerol [plasma membrane]' [PositiveRegulation:400515] Positive regulation by 'FFAR4:FFAR4 ligands [plasma membrane]' [PositiveRegulation:400545] Positive regulation by 'AcCho [extracellular region]' [PositiveRegulation:400558] Positive regulation by 'Glc [extracellular region]' [PositiveRegulation:400559] Positive regulation by 'Gustducin Complex (alpha, beta, gamma subunits) [plasma membrane]' [PositiveRegulation:416524] Positive regulation by 'FFAR1:FFAR1 ligands [plasma membrane]'
regulationReference	[RegulationReference:9641366] Positive regulation by 'LEP [extracellular region]' Role of leptin in the regulation of glucagon-like peptide-1 secretion [RegulationReference:9641702] Positive regulation by 'GPR119:monoacylglycerol [plasma membrane]' A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release [RegulationReference:9642209] Positive regulation by 'AcCho [extracellular region]' Biology of incretins: GLP-1 and GIP [RegulationReference:9642758] Positive regulation by 'FFAR1:FFAR1 ligands [plasma membrane]' Biology of incretins: GLP-1 and GIP [RegulationReference:9642873] Positive regulation by 'Glc [extracellular region]' Biology of incretins: GLP-1 and GIP [RegulationReference:9642947] Positive regulation by 'FFAR4:FFAR4 ligands [plasma membrane]' Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
releaseDate	2010-09-21
reviewed	[InstanceEdit:879883] Bloom, SR, 2010-06-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104348] R-HSA-383313.5
summation	[Summation:383314] Secretion of GLP-1 from intestinal L-cells is dependent on a... [Summation:400518] The G-protein coupled receptor Alpha-Gustducin is present in...
(hasEvent)	[Pathway:381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) [Homo sapiens]
(precedingEvent)	[Reaction:381612] GLP1R binds GLP1 [Homo sapiens] [Reaction:9023632] DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) [Homo sapiens] [Reaction:9023633] DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775707] Update Tracker - [BlackBoxEvent:383313] Glucagon-like Peptide 1 is secreted from intestinal L cells - v78:[addSummation] [_UpdateTracker:9787621] Update Tracker - [BlackBoxEvent:383313] Glucagon-like Peptide 1 is secreted from intestinal L cells - v44:[add_removeOutput]
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