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Details on Person ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix

Class:IdReaction:382575
_displayNameABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix
_doReleaseTRUE
_timestamp2025-12-30 14:34:53
authored[InstanceEdit:382535] Gopinathrao, G, 2008-11-23 14:00:06
catalystActivity[CatalystActivity:382568] long-chain fatty acid transmembrane transporter activity of ABCD1-3 dimers [peroxisomal membrane]
compartment[Compartment:17947] peroxisomal membrane
[Compartment:70101] cytosol
[Compartment:17951] peroxisomal matrix
created[InstanceEdit:382574] Gopinathrao, G, 2008-11-23 16:44:55
edited[InstanceEdit:382574] Gopinathrao, G, 2008-11-23 16:44:55
input[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:8876730] LCFA(-) [cytosol]
internalReviewed[InstanceEdit:9978289] D'Eustachio, Peter, 2025-12-29
literatureReference[LiteratureReference:387009] Adrenoleukodystrophy gene: unexpected homology to a protein involved in peroxisome biogenesis
[LiteratureReference:382588] Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p
[LiteratureReference:382598] Characterization and functional analysis of the nucleotide binding fold in human peroxisomal ATP binding cassette transporters
[LiteratureReference:386995] PMP70, the 70-kDa peroxisomal membrane protein: a member of the ATP-binding cassette transporters
[LiteratureReference:387021] ATP-binding cassette (ABC) transporters in human metabolism and diseases
modified[InstanceEdit:382590] Gopinathrao, G, 2008-11-23 16:45:13
[InstanceEdit:383191] Gopinathrao, G, 2008-11-24 14:15:13
[InstanceEdit:383209] Gopinathrao, G, 2008-11-24 14:20:29
[InstanceEdit:387028] Gopinathrao, G, 2008-11-29 15:54:33
[InstanceEdit:387475] Gopinathrao, G, 2008-12-02 18:01:35
[InstanceEdit:387486] Gopinathrao, G, 2008-12-02 18:04:50
[InstanceEdit:975967] Jassal, Bijay, 2010-10-11
[InstanceEdit:1050115] D'Eustachio, P, 2010-11-24
[InstanceEdit:1368972] Jassal, Bijay, 2011-07-04
[InstanceEdit:1472887] Jassal, Bijay, 2011-08-04
[InstanceEdit:1502534] Jassal, Bijay, 2011-08-23
[InstanceEdit:5684049] Jassal, Bijay, 2015-03-18
[InstanceEdit:9640580] D'Eustachio, Peter, 2019-03-29
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9978272] D'Eustachio, Peter, 2025-12-29
[InstanceEdit:9978288] D'Eustachio, Peter, 2025-12-29
[InstanceEdit:9978313] D'Eustachio, Peter, 2025-12-30
nameABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix
output[SimpleEntity:382571] LCFA [peroxisomal matrix]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29372] Pi [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2008-12-17
reviewed[InstanceEdit:387472] Matthews, L, 2008-12-02 15:41:53
[InstanceEdit:1502533] D'Eustachio, P, 2011-08-23
[InstanceEdit:9978314] D'Eustachio, Peter, 2025-12-30
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:387585] R-HSA-382575.4
structureModified[InstanceEdit:9978272] D'Eustachio, Peter, 2025-12-29
summation[Summation:387014] The 70-kDa peroxisomal membrane protein (PMP70) and the adre...
(hasEvent)[Pathway:1369062] ABC transporters in lipid homeostasis [Homo sapiens]
(normalReaction)[FailedReaction:5684043] Defective ABCD1 does not transfer LCFAs from cytosol to peroxisomal matrix [Homo sapiens]
(precedingEvent)[Reaction:390427] 1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate [Homo sapiens]
(updatedInstance)[_UpdateTracker:9784735] Update Tracker - [Reaction:382575] ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix - v53:[modifyText]
[_UpdateTracker:9789310] Update Tracker - [Reaction:382575] ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix - v38:[modifyText]
[_UpdateTracker:9790169] Update Tracker - [Reaction:382575] ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix - v35:[add_removeInput, add_removeOutput]
[_UpdateTracker:9984597] Update Tracker - [Reaction:382575] ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix - v96:[add_removeInput]
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