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Details on Person ABCA7:Apo1A-mediated phospholipid efflux

Class:Id	Reaction:382553
_displayName	ABCA7:Apo1A-mediated phospholipid efflux
_doRelease	TRUE
_timestamp	2011-08-23 06:42:34
authored	[InstanceEdit:382535] Gopinathrao, G, 2008-11-23 14:00:06
catalystActivity	[CatalystActivity:382563] phospholipid transfer activity of ABCA7-1:ApoA1 complex [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:382535] Gopinathrao, G, 2008-11-23 14:00:06
edited	[InstanceEdit:382535] Gopinathrao, G, 2008-11-23 14:00:06
input	[DefinedSet:382526] ABCA7-dependent phospholipids [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:382532] ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux [LiteratureReference:382528] Role of ABC transporters in secretion of cholesterol from liver into bile [LiteratureReference:382548] Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release [LiteratureReference:382549] Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7) [LiteratureReference:387010] Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein [LiteratureReference:382541] Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene
modified	[InstanceEdit:383209] Gopinathrao, G, 2008-11-24 14:20:29 [InstanceEdit:387028] Gopinathrao, G, 2008-11-29 15:54:33 [InstanceEdit:387475] Gopinathrao, G, 2008-12-02 18:01:35 [InstanceEdit:387486] Gopinathrao, G, 2008-12-02 18:04:50 [InstanceEdit:1368972] Jassal, Bijay, 2011-07-04 [InstanceEdit:1500948] Jassal, Bijay, 2011-08-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ABCA7:Apo1A-mediated phospholipid efflux
output	[DefinedSet:382530] ABCA7-dependent phospholipids [extracellular region] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol]
releaseDate	2008-12-17
reviewed	[InstanceEdit:387472] Matthews, L, 2008-12-02 15:41:53
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:387631] R-HSA-382553.2
summation	[Summation:387015] ABCA7 has the ability to bind apolipoproteins and promote ef...
(hasEvent)	[Pathway:1369062] ABC transporters in lipid homeostasis [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9789263] Update Tracker - [Reaction:382553] ABCA7:Apo1A-mediated phospholipid efflux - v38:[addInput, addOutput]
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No pathways have been reviewed or authored by ABCA7:Apo1A-mediated phospholipid efflux (382553)