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Details on Person PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP

Class:Id	Reaction:381707
_displayName	PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP
_doRelease	TRUE
_timestamp	2024-02-12 20:42:58
authored	[InstanceEdit:164336] Gopinathrao, G, 2005-05-18 22:14:39
catalystActivity	[CatalystActivity:381625] cAMP binding activity of PKA:AKAP79:IQGAP1 Complex [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:381677] May, B, 2008-11-19 21:15:12
edited	[InstanceEdit:422341] May, B, 2009-05-28 03:44:04
inferredFrom	[Reaction:446974] cAMP Induces dissociation of active protein kinase A subunits from the PKA:Akap150:Iqgap1 complex [Rattus norvegicus]
input	[SimpleEntity:30389] cAMP [cytosol] [SimpleEntity:30389] cAMP [cytosol] [SimpleEntity:30389] cAMP [cytosol] [SimpleEntity:30389] cAMP [cytosol] [Complex:381635] PKA:AKAP79:IQGAP1 Complex [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:381700] Mechanisms of action of glucagon-like peptide 1 in the pancreas [LiteratureReference:381663] Protein kinase A translocation and insulin secretion in pancreatic beta-cells: studies with adenylate cyclase toxin from Bordetella pertussis [LiteratureReference:381726] Identification of an IQGAP1/AKAP79 complex in beta-cells [LiteratureReference:381641] Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential
modified	[InstanceEdit:383210] Gopinathrao, G, 2008-11-24 14:43:07 [InstanceEdit:422156] D'Eustachio, P, 2009-05-26 22:29:40 [InstanceEdit:422326] May, B, 2009-05-28 03:43:02 [InstanceEdit:422556] D'Eustachio, P, 2009-06-02 01:00:41 [InstanceEdit:425252] May, B, 2009-06-03 [InstanceEdit:446973] May, B, 2009-11-19 [InstanceEdit:5252146] May, B, 2014-02-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9857008] D'Eustachio, Peter, 2023-12-29 [InstanceEdit:9860913] D'Eustachio, Peter, 2024-02-12
name	PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP
output	[DefinedSet:111920] PKA catalytic subunit [cytosol] [Homo sapiens] [DefinedSet:111920] PKA catalytic subunit [cytosol] [Homo sapiens] [Complex:381615] cAMP:PKA:AKAP79:IQGAP1 Complex [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:381607] Activated Adenylyl cyclase synthesizes cyclic AMP [Homo sapiens] [Reaction:381704] G(s):GTP activates Adenylyl cyclase [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2009-06-24
reviewed	[InstanceEdit:422557] Gillespie, ME, 2009-06-02 00:59:01 [InstanceEdit:9860914] Hill, David P, 2024-02-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105949] R-HSA-381707.3
structureModified	[InstanceEdit:9857008] D'Eustachio, Peter, 2023-12-29
summation	[Summation:381624] The inactive Protein Kinase A (PKA) complex contains 2 regul...
(hasEvent)	[Pathway:381676] Glucagon-like Peptide-1 (GLP1) regulates insulin secretion [Homo sapiens]
(precedingEvent)	[Reaction:265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel [Homo sapiens] [BlackBoxEvent:381644] ER calcium channels open in response to activated PKA [Homo sapiens] [BlackBoxEvent:381713] Potassium voltage-gated channels close in reponse to PKA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9864184] Update Tracker - [Reaction:381707] PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP - v88:[addCatalystActivity, modifyText]
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No pathways have been reviewed or authored by PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP (381707)