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Details on Person cAMP activates EPAC2

Class:Id	Reaction:381608
_displayName	cAMP activates EPAC2
_doRelease	TRUE
_timestamp	2024-02-12 20:43:17
authored	[InstanceEdit:422324] May, B, 2009-05-28 03:42:50
catalystActivity	[CatalystActivity:400567] cAMP binding activity of RAPGEF4 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:381677] May, B, 2008-11-19 21:15:12
edited	[InstanceEdit:422324] May, B, 2009-05-28 03:42:50
input	[EntityWithAccessionedSequence:3008666] RAPGEF4 [plasma membrane] [Homo sapiens] [SimpleEntity:30389] cAMP [cytosol] [SimpleEntity:30389] cAMP [cytosol]
literatureReference	[LiteratureReference:381645] Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells [LiteratureReference:446661] Expression of cAMP-regulated guanine nucleotide exchange factors in pancreatic beta-cells [LiteratureReference:446916] Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells [LiteratureReference:446917] cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells [LiteratureReference:381697] Cell physiology of cAMP sensor Epac [LiteratureReference:381700] Mechanisms of action of glucagon-like peptide 1 in the pancreas [LiteratureReference:381641] Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential [LiteratureReference:381690] Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2.Piccolo complex in cAMP-dependent exocytosis
modified	[InstanceEdit:383210] Gopinathrao, G, 2008-11-24 14:43:07 [InstanceEdit:400566] May, B, 2009-03-24 04:10:22 [InstanceEdit:422156] D'Eustachio, P, 2009-05-26 22:29:40 [InstanceEdit:422309] May, B, 2009-05-28 03:41:21 [InstanceEdit:422556] D'Eustachio, P, 2009-06-02 01:00:41 [InstanceEdit:425244] May, B, 2009-06-03 [InstanceEdit:446670] May, B, 2009-11-16 [InstanceEdit:446921] May, B, 2009-11-19 [InstanceEdit:3008669] Jassal, B, 2013-02-01 [InstanceEdit:5252146] May, B, 2014-02-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9857008] D'Eustachio, Peter, 2023-12-29 [InstanceEdit:9860913] D'Eustachio, Peter, 2024-02-12
name	cAMP activates EPAC2
output	[Complex:381680] RAPGEF4:cAMP Complex [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:381607] Activated Adenylyl cyclase synthesizes cyclic AMP [Homo sapiens] [Reaction:381704] G(s):GTP activates Adenylyl cyclase [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2009-06-24
reviewed	[InstanceEdit:422557] Gillespie, ME, 2009-06-02 00:59:01 [InstanceEdit:9860914] Hill, David P, 2024-02-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105741] R-HSA-381608.3
structureModified	[InstanceEdit:9857008] D'Eustachio, Peter, 2023-12-29
summation	[Summation:381622] Each molecule of EPAC2 / RAPGEF4 binds 2 molecules of cAMP. ...
(hasEvent)	[Pathway:381676] Glucagon-like Peptide-1 (GLP1) regulates insulin secretion [Homo sapiens]
(precedingEvent)	[Reaction:381727] RAP1A exchanges GDP for GTP [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788090] Update Tracker - [Reaction:381608] cAMP activates EPAC2 - v44:[add_removeInput] [_UpdateTracker:9791331] Update Tracker - [Reaction:381608] cAMP activates EPAC2 - v31:[addLiteratureReference] [_UpdateTracker:9864291] Update Tracker - [Reaction:381608] cAMP activates EPAC2 - v88:[addCatalystActivity, modifyText]
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No pathways have been reviewed or authored by cAMP activates EPAC2 (381608)