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Details on Person IGFBP6 binds IGF forming IGF:IGFBP6

Class:IdReaction:381503
_displayNameIGFBP6 binds IGF forming IGF:IGFBP6
_doReleaseTRUE
_timestamp2018-01-10 16:53:56
compartment[Compartment:984] extracellular region
created[InstanceEdit:381505] May, B, 2008-11-19 20:29:10
edited[InstanceEdit:381443] May, B, Gopinathrao, G, 2008-11-19 20:02:07
input[DefinedSet:381451] IGF1,2 [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:381475] IGFBP6 [extracellular region] [Homo sapiens]
literatureReference[LiteratureReference:535671] Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6
[LiteratureReference:535695] Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography
[LiteratureReference:535650] Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting
[LiteratureReference:538692] Contributions of the N- and C-terminal domains of IGF binding protein-6 to IGF binding
[LiteratureReference:381401] The role of insulin-like growth factor binding proteins
[LiteratureReference:538733] Recombinant human insulin-like growth factor (IGF)-binding protein-6 inhibits IGF-II-induced differentiation of L6A1 myoblasts
[LiteratureReference:538723] C-terminal domain of insulin-like growth factor (IGF) binding protein-6: structure and interaction with IGF-II
[LiteratureReference:538763] O-glycosylation of insulin-like growth factor (IGF) binding protein-6 maintains high IGF-II binding affinity by decreasing binding to glycosaminoglycans and susceptibility to proteolysis
[LiteratureReference:381400] Cellular actions of the insulin-like growth factor binding proteins
[LiteratureReference:381407] IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms
modified[InstanceEdit:383210] Gopinathrao, G, 2008-11-24 14:43:07
[InstanceEdit:387204] May, B, 2008-12-01 11:42:19
[InstanceEdit:387469] Gopinathrao, G, 2008-12-02 17:52:42
[InstanceEdit:535673] May, B, 2010-03-04
[InstanceEdit:538768] May, B, 2010-03-08
[InstanceEdit:5252148] May, B, 2014-02-05
[InstanceEdit:8952339] Jupe, Steve, 2016-12-14
[InstanceEdit:9034706] May, Bruce, 2018-01-10
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameIGFBP6 binds IGF forming IGF:IGFBP6
output[Complex:381482] IGF:IGFBP6 [extracellular region] [Homo sapiens]
releaseDate2008-12-17
reviewed[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:387767] R-HSA-381503.4
summation[Summation:381453] IGFBP-6 binds IGF I or IGF II via the conserved N terminus a...
(hasEvent)[Pathway:381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) [Homo sapiens]
(updatedInstance)[_UpdateTracker:9779839] Update Tracker - [Reaction:381503] IGFBP6 binds IGF forming IGF:IGFBP6 - v64:[removeCatalystActivity]
[_UpdateTracker:9790656] Update Tracker - [Reaction:381503] IGFBP6 binds IGF forming IGF:IGFBP6 - v33:[add_removeLiteratureReference, modifyText]
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